| 去泛素化酶与肿瘤相关性的研究进展 |
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| 引用本文： | 张悦,师永红. 去泛素化酶与肿瘤相关性的研究进展[J]. 内蒙古医学杂志, 2014, 0(5): 561-563 |
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| 作者姓名： | 张悦 师永红 |
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| 作者单位： | [1]内蒙古医科大学,内蒙古呼和浩特010059 [2]内蒙古医科大学附属医院病理科,内蒙古呼和浩特010050 |
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| 基金项目： | 国家自然科学基金（81360395） |
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| 摘 要： | 泛素-蛋白酶体途径是大多数细胞内蛋白质降解的主要方式,去泛素化酶（Deubiquitinating enzymes,DUBs）可以逆转这一过程,对其进行反向调节.此外,去泛素化酶可以稳定抑癌基因,从而抑制了肿瘤的发生.对去泛素化酶及其抑制剂的深入研究,为抗肿瘤药物的靶向治疗提供理论依据.本文将重点对去泛素化酶及其在肿瘤中的作用进行综述.
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| 关 键 词： | 泛素化 去泛素化 泛素-蛋白酶体途径 DUBs |
Research Progress of the Correlation of Deubiquitinating Enzymes with Tumor |
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| Affiliation: | ZHANG Yue, SHI Yong - hong (1. Inner Mongolia Medical University, Hohhot 010059 China ;2. Deparement of Pathology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050 China ) |
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| Abstract: | Ubiquitin- proteasome pathway is the main way in the degredation of most cell protein. De - u- biquitinating enzymes （Deubiquitinating enzymes, DUBs） can reverse this process and regulate on the contrary. In addition, de - ubiquitinating enzymes can stabilize the tumor suppressor gene, thus inhibiting tumorigenesis. Indepth study of the de - ubiquitinating enzymes and their inhibitors provide a theoretical basis for the targeted treatment of anticancer drugs. This review will focus on de - ubiquitinating enzymes and their role in tumor. |
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| Keywords: | ubiquitination deubiquitination ubiquitin - proteasome pathway DUBs |
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