| 自噬分子机制与疾病研究进展 |
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| 引用本文： | 孙亮,;刘万林. 自噬分子机制与疾病研究进展[J]. 内蒙古医学杂志, 2014, 0(7): 818-821 |
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| 作者姓名： | 孙亮, 刘万林 |
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| 作者单位： | [1]内蒙古医科大学,内蒙古呼和浩特010059; [2]内蒙古医科大学第二附属医院骨科,内蒙古呼和浩特010030 |
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| 基金项目： | 国家自然科学基金资助（项目编号：81360273） |
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| 摘 要： | 自噬是不同于凋亡的另一种程序性细胞死亡。它可以清除体内的异常蛋白质、病原微生物以及一些受损的细胞器。另外在清除上述物质的同时,自噬还可以促进细胞衰老和细胞表面抗原的表达,维持基因组的稳定性和防止坏死,在预防一些疾病中有重要作用,如肿瘤、神经退化性疾病及免疫系统疾病等。本文就自噬在分子水平上是如何调控以及与疾病相关性做一简要综述。
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| 关 键 词： | 自噬 分子机制 疾病 |
Prospective of Autophagy Involved in Molecular Mechanism and Disdases |
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| Affiliation: | SUN Liang, LIU Wan - lin (1. Inner Mongolia Medical College, Hohhot 010059 China ; 2. Department of Orthopedics, Second Affiliated Hospital of Inner Mongolia, Hohhot 010030 China ) |
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| Abstract: | Autophagy is another programmed cell death different from apoptosis.It can clear abnormal proteins,pathogens and some damaged organelles of the body.Further,while the removal of the substances above,it can also promote the expression of autophagic cell senescence and cell surface antigens,to maintain genomic stability and to prevent necrosis,it have an important role in the prevention of several diseases,such as cancer,neurodegenerative diseases and immune system diseases.This article make a brief overview of autophagy at the molecular level and correlation with disease. |
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| Keywords: | autophagy molecular mechanisms disease |
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