| 碱性成纤维生长因子对豚鼠庆大霉素肾毒性损伤的保护作用 |
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| 引用本文： | 魏佑震,黄庆玉,申姜颖,洪岸,康颂建. 碱性成纤维生长因子对豚鼠庆大霉素肾毒性损伤的保护作用[J]. 解剖学研究, 2001, 23(4): 310-312 |
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| 作者姓名： | 魏佑震 黄庆玉 申姜颖 洪岸 康颂建 |
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| 作者单位： | 1. 山东泰山医学院脑研究室,泰安,271000
2. 暨南大学生物工程研究所,广州,510632 |
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| 摘 要： | 目的 研究碱性成纤维细胞生长因子 (bFGF)对庆大霉素 (GE)所致豚鼠肾损伤的拮抗作用。方法 2 0只豚鼠随机分成三组 ,正常对照组 (N ,n =6) ,庆大霉素对照组 (G ,n =7) ,庆大霉素bFGF组 (F ,n =7)。G组 :GE 80mg·kg- 1 ·d- 1 肌肉注射 ,连续 1 5d ;F组 :bFGF肌肉注射 80 0U·kg- 1 ·d- 1 ,相隔 1～ 2h后加GE 80mg·kg- 1 ·d- 1 肌肉注射 ,连续 1 5d。第 1 6d取肾固定 ,石蜡包埋切片 ,HE染色 ,光镜观察肾小球、肾小管及肾间质。结果 F组与G组比较 ,F组肾小球毛细血管扩张、充血及内皮细胞肿胀较轻 ;肾小管坏死数量较少 ;肾小管再生、肾间质炎细胞浸润和纤维细胞增生明显。结论 bFGF对豚鼠庆大霉素肾损伤具有预防保护作用
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| 关 键 词： | 成纤维细胞生长因子 豚鼠 肾 庆大霉素 |
| 修稿时间： | 2001-10-06 |
The protection effect of basic fibroblast factor on guinea pig toxic kidney injury induced by gentamicin |
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| Wen Youzhen,Huang Qingyu,Shen Jiangying,Hong An,Kang Songjian. The protection effect of basic fibroblast factor on guinea pig toxic kidney injury induced by gentamicin[J]. Anatomy Research, 2001, 23(4): 310-312 |
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| Authors: | Wen Youzhen Huang Qingyu Shen Jiangying Hong An Kang Songjian |
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| Abstract: | Objective To study the antitoxic effect of basic fibroblast growth factor(bFGF) against guinea pig kidney injury induced by gentamicin. Method Gentamicin control group(G) was injected gentamicin 80mg·kg -1 ·d -1 im.for 15d;gentamicin & bFGF group(F) was injected with bFGF 800U·kg -1 ·d -1 im. and gentamicin 80mg·kg -1 ·d -1 im.for 15d. On the 16th day,the guinea pigs were killed and the kidney were detected by microscope. Result Compare with group G,capillary ectasia of renal corpuscle,hyperemia,endodermis cell swollen were lighter;necrosis of renal tubule was lesser;regeneration of renal tubule and fibre cell,infiltrate of inflammation cell were more distinctness in group F. Conclusion bFGF has protective effect on guinea pig kidney injury induced by gentamicin. |
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| Keywords: | Basic fibroblast factor Guinea pig Kidney Gentamicin |
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