氟比洛芬酯注射液预防老年患者全麻苏醒期躁动的临床观察

目的 观察氟比洛芬酯预防老年患者全麻苏醒期躁动的作用.方法 60例ASA Ⅰ～Ⅱ级择期上腹部手术老年患者,随机分为对照组(n=15),试验组1(切皮前静脉给予氟比洛芬酯50mg,n=15),试验组2(缝皮时静脉给予氟比洛芬酯50 mg,n=15),试验组3(切皮前及术毕缝皮时均静脉给予氟比洛芬酯50mg,n=15).观察手术时间、麻醉维持时间、清醒时间及拔管时间;监测苏醒期心率(HR)、平均动脉压(MAP)、血氧饱和度(SpO2)及躁动评分、镇静评分身体舒适度评分;术后24 h随访副作用.结果 4组患者性别、年龄、体重、手术时间、拔管时间及苏醒时间差异无统计学意义.与对照组相比.各试验组在术毕后各时点的HR,MAP均显著降低(P<0.05). 4组患者在各观察时点的SpO2无统计学差异.各试验组在各观察时点的躁动评分均显著低于对照组(P<0.05),Ramsay镇静评分均显著高于对照组(P<0.05).拔管后10 min,各试验组的身体舒适度评分均显著高于对照组(P

Flurbiprofen axe til injection prevents restlessness during analepsia from general anesthesia in elderly patients

Objective To evaluate the preventive effect of flurbiprofen axetil on restlessness during analepsia from gen-eral anesthesia in elderly patients.Methods Sixty elderly patients with ASA grade Ⅰ-Ⅱ,undergoing selective operation at epigagtric zone were randomly divided into 1 control group and 3 test groups(n=15).Flurbiprofen axetil (50 mg) was admin-istrated before incising the skin (test group 1),before suturing the skin(test group 2)or both before incising and suturing the skin(test group 3).HR,MAP,SpO2,Resdessness Score,Bamsay Sedative Score and Body Comfort Score were monitored and assessed duffng analepsia.Adverse effects were subsequently visited after operation.Results There is no difference in gender ration,age,body weisht,duration of operation and anesthesia,time for extubation and analepsia among four groups-HR and MAP in test grouPs were lower than that in control group(P<0.05),and no difference in SpO2 wag observed among four groups.Restiessness Score was apparently lower and Ramsay Sedative Score,Body Comfort Score was signitieandy higher in test groups than in control group(P<0.05).During post-operative 24 h.skin itch and vomiting occurred in one case each from teBt greup 1 and test group 3,respectively.Conclusion It is safe and feasible of using flurbiprofen axetil to prevent restlessness during analepsia in elderly patients.