Combined "Mixed Medullary-Follicular" and "Papillary" Carcinoma of the Thyroid with Lymph Node Metastasis |
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| Authors: | Shimizu Michio Hirokawa Mitsuyoshi LiVolsi Virginia A. Mizukami Yuji Harada Tanekazu Itoh Tomoo Manabe Toshiaki |
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| Affiliation: | (1) First Department of Pathology, School of Medicine, University of Tokushima, Tokushima;(2) Department of Pathology, University of Pennsylvania Medical Center, Philadelphia, PA;(3) School of Health Sciences, Faculty of Medicine, Kanazawa University, Kanazawa;(4) Kawasaki College of Allied Health Professions, Kurashiki;(5) Department of Pathology, Kawasaki Medical School, Kurashiki;(6) Department of Surgical Pathology, Hokkaido University Hospital, North 14, West 5, Kita-ku, 060-8648 Sapporo, Japan |
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| Abstract: | We report a case of combined “mixed medullary-follicular” and “papillary” carcinoma of the thyroid that occurred in a 44-yr-old Japanese woman. The grossly single 3 cm tumor was histologically composed of both mixed medullary-follicular carcinoma and papillary carcinoma, which abutted against each other with a clear border between two components. Immunohistochemically, the component of medullary carcinoma was positive for calcitonin and carcinomebryonic antigen (CEA), and the follicular carcinoma and papillary carcinoma components were positive for thyroglobulin. Lymph node metastasis was also noted. The patient has been alive without recurrence for 20 yr. To the best of our knowledge, this is the first reported case in the literature. We report this unique case of thyroid carcinoma and review related thyroid malignancies. |
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| Keywords: | Thyroid mixed medullary-follicular carcinoma papillary carcinoma lymph node metastasis combined carcinoma |
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