诱导HO-1基因表达的信号通路

血红素氧合酶（HO）的诱导型HO-1与其催化血红素降解生成的产物胆红素和CO一道，组成了机体重要的内源性保护系统，广泛参与抗炎与多种急慢性氧化应激损伤。多种理化因素通过不同的细胞内信号转导通路诱导HO-1的表达，这些信号通路涉及丝裂原活化蛋白激酶（MAPKs）、蛋白激酶C(PKC)、cAMP依赖的蛋白激酶A(PKA)、cGMP依赖蛋白激酶G（PKG）、酪氨酸蛋白激酶（TPK）、蛋白磷酸酶（PPs）、磷脂酰肌醇（-3）激酶（PI3K）/Akt

Signal transduction pathways of heme oxygenase-1 gene expression

Heme oxygenase-1(HO-1),the inducible isoform of heme oxygenase,and biliverdin as well as carbon monoxide,the product of HO1 degrading heme,constitute the major endogenous protective system in organism, which widely participates in anti-inflammatory and multiple acute and chronic oxidative stress injury.Many physical and chemical factors induce HO-1 expression by various intracellular signal transduction pathways,such as mitogen-activated protein kinases(MAPKs),protein kinase C(PKC),cAMP-dependentprotein kinase A(PKA),cGMP-dependent protein kinase G(PKG),tyrosine protein kinase(TPK),protein phosphatase(PPs),and phosphatidylinositol 3-kinase(PI3K).There is a significance in preventing and treating diseases that studying and illuminating these pathways reasonably regulates HO-1 expression.