阿立哌唑与坦度螺酮联合应用改善女性精神分裂症患者认知功能

目的 探讨阿立哌唑和坦度螺酮联用对女性精神分裂症患者认知功能的影响.方法 91例女性精神分裂症患者随机分成两组,实验组(阿立哌唑联用坦度螺酮)47例,对照组(阿立哌唑)44例,治疗8周,在治疗前后采用阳性与阴性症状量表PANSS评定临床疗效,采用威斯康星卡片分类测验WCST以及注意广度测验评定认知功能,采用副作用量表TENSS评定不良反应.结果 治疗后两组PANSS评分较治疗前显著下降(P＜0.01).治疗后两组认知症状均有所改善.实验组认知测验中言语记忆、数字序列、持续操作、完成分类数高于对照组(P ＜0.05或0.01),错误应答数、非持续错误数低于对照组(P＜0.05或0.01).两组不良反应轻微,对照组患者出现震颤的例数显著增多(P＜0.05).结论 阿立哌唑联合坦度螺酮治疗精神分裂症可有效改善精神分裂症患者的认知功能.

Aripiprazole combing tandospirone can improve cognitive function of female schizophrenic patients

Objective To explore the effect of aripiprazole combing tandospirone in cognitive function of schizophrenic patients. Method Ninety-one patients with schizophrenia were randomly divided into the controlled group(aripiprazole combing tandospirone n=47)and the matched group (aripiprazole n=44). Clinical efficacy was evaluated by Positive and Negative Symptoms Scale(PANSS)at baseline and 8 weeks. Cognitive function was assessed by Wisconsion Card Sorting Test(WCST)and Attention span test. Results The effect of these two groups has improved greatly, (P﹤0.01), At the end of the 8th week, verbal memory, sequence of number, continuous operation, categories completed improved more significantly compared with patients without tandospirone,( P﹤0.05 or 0.01). Response errors and non-persistent errors lower than patients without tandospirone, (P﹤0.05 or 0.01).The adverse reaction of the two group is few. Many patient without tandospirone caused tremor, which showed great significant differences(P﹤0.05). Conclusion Aripiprazole combing Tandospirone can improve cognitive function of female schizophrenic patients.