DDT and DDE exposure in mothers and time to pregnancy in daughters |
| |
Authors: | Cohn Barbara A Cirillo Piera M Wolff Mary S Schwingl Pamela J Cohen Richard D Sholtz Robert I Ferrara Assiamira Christianson Roberta E van den Berg Barbara J Siiteri Pentti K |
| |
Affiliation: | Child Health and Development Studies, Center for Research on Women's and Children's Health, Public Health Institute, 1683 Shattuck Avenue, Suite B, Berkeley, CA 94709, USA. crwch@emf.net |
| |
Abstract: | Reproductive-tract anomalies after administration of the potent oestrogen, diethylstilboestrol, in pregnant women raised concerns about the reproductive effects of exposure to weakly oestrogenic environmental contaminants such as bis[4-chlorophenyl]-1,1,1-trichloroethane (p,p'-DDT) or its metabolites, such as bis[4-chlorophenyl]-1,1-dichloroethene (p,p'-DDE). We measured p,p'-DDT and p,p'-DDE in preserved maternal serum samples drawn 1-3 days after delivery between 1960 and 1963. We recorded time to pregnancy in 289 eldest daughters 28-31 years later. Daughters' probability of pregnancy fell by 32% per 10 microg/L p,p'-DDT in maternal serum (95% CI 11-48). By contrast, the probability of pregnancy increased 16% per 10 microg/L p,p'-DDE (6-27). The decreased fecundability associated with prenatal p,p'-DDT remains unexplained. We speculate that the antiandrogenic activity of p,p'-DDE may mitigate harmful androgen effects on the ovary during gestation or early life. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|