人工麝香对大鼠高脂血症影响的实验研究

目的：观察人工麝香对大鼠高脂血症的影响。方法：SD大鼠,随机分为6组,每组10只。空白组正常饲养,其余5组高脂乳剂灌胃同时给药,连续4周。末次给药后1 h,取血离心制备血清,检测TC、TG、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）含量,用双抗体夹心ELISA法测定血清C反应蛋白（CRP）、内皮素-1（ET-1）、肿瘤坏死因子α（TNF-α）的变化。结果：与模型组比较,人工麝香低、中、高剂量（3、6、12 mg/kg）能明显降低TC、TG的升高（P〈0.05）,对LDL-C的升高有一定的降低作用;人工麝香高剂量能明显降低大鼠血清CRP、ET-1、TNF-α（P〈0.05）。结论：人工麝香对大鼠高脂血症具有明显的调节作用。

Effects of artificial musk on hyperlipemia in rats

AIM：To investigate the effect of artificial musk on hyperlipermia in rats. METHODS：SD rats were randomly divided into six groups：control group,model group,simvastatin group,artificial musk low,middle and high groups.The fatty emulsion were given to model group and treated groups,but none to control group.The levels of total cholesterol（TC）,triglyceride（TG）,low density lipoprotein cholesterol（LDL-C） and high density lipoprotein cholesterol（HDL-C） were measured.The levels of serum CRP,ET-1 and TNF-α were determined by double-antibody sandwich ELISA.RESULTS：The function in reducing the content of serum TC,TG were different between artificial groups and model group（P0.05）.Artificial musk high dose group decreased the serum levels of CRP,ET-1 and TNF-α（P0.05）.CONCLUSION：Artificial musk can improve hyperlipermia in rats.