| 大肠癌ras p21表达和DNA含量定量分析 |
| |
| 引用本文： | 徐亮,卢光宇.大肠癌ras p21表达和DNA含量定量分析[J].中国普外基础与临床杂志,1998,5(1):4-6. |
| |
| 作者姓名： | 徐亮 卢光宇 |
| |
| 作者单位： | [1]四川省泸州医学院附属医院胃肠外科 [2]中山医科大学附一院 |
| |
| 摘 要： | 应用流式细胞术和细胞免疫荧光染色技术，对４６例大肠肿瘤细胞ｒａｓ ｐ２１表达和ＤＮＡ含量进行了宣分析。结果：大肠部的ｒａｓ ｐ２１表达阳性率为６５．７％，ＤＮＡ异倍体率为７４．３％，大肠部细胞ｒａｓ ｐ２１表达明显高于腺癌和正常粘膜；ＤＮＡ倍体和细胞增殖指数值与ｒａｓ ｐ２１表达量密切相关。本实验结果提示：测定大肠癌的ｒａｓ ｐ２１表达和ＤＮＡ含量将有助于其预后判断。
|
| 关 键 词： | 大肠癌 ras p21 DNA |
QUANTITATIVE STUDY OF RAS P21 EXPRESSION AND DNA CONTENT IN COLORECTAL CANCERS |
| |
| Xu Liang,Lu Guangyu.QUANTITATIVE STUDY OF RAS P21 EXPRESSION AND DNA CONTENT IN COLORECTAL CANCERS[J].Chinese Journal of Bases and Clinics In General Surgery,1998,5(1):4-6. |
| |
| Authors: | Xu Liang Lu Guangyu |
| |
| Institution: | Xu Liang,Lu Guangyu. Department of Gastroenterology Surgery,Affiliated Hospital,Luzhou Medical College,Luzhou 646000 |
| |
| Abstract: | The oncogene ras p21 expression and DNA content in 46 cases of colorectal tumor were analysed quantitatively with flow cytometry and cyto immunofluorescence staining technique. The results showed that the positive rate of ras p21 expression was 65.7% and the rate of DNA aneuploid was 74.3% in colorectal carcinomas. Ras p21 expression was higher in colorectal adenocarcinomas than that of the adenomas and normal mucosa. DNA ploid and proliferative index had some association with ras p21 expresssion. Detection of ras p21 expression and DNA content in tumors may be helpful in predicting the outcome of colorectal cancer patients. |
| |
| Keywords: | Colorectal carcinoma Ras p21 Deoxyribonucleic acid content |
| 本文献已被 CNKI 维普 等数据库收录！ |
