| 硝酸异山梨酯静脉内输注治疗冠心病心绞痛102例 |
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| 引用本文： | 徐济民,黄震华,郑慧君,林淑英,李进禧,朱亮,陆琛.硝酸异山梨酯静脉内输注治疗冠心病心绞痛102例[J].中国新药与临床杂志,1997(1). |
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| 作者姓名： | 徐济民 黄震华 郑慧君 林淑英 李进禧 朱亮 陆琛 |
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| 作者单位： | 上海第二医科大学附属第九人民医院，上海第二医科大学附属瑞金医院，上海第二医科大学附属仁济医院，上海第一生化药业公司 |
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| 摘 要： | 目的：比较国产与进口硝酸异山梨酯注射液治疗冠心病心绞痛的疗效。方法：冠心病心绞痛病人１５２例，其中１０２例（男性６７例，女性３５例，年龄６３±ｓ９ａ）以国产硝酸异山梨酯注射液２０ｍｇ加于５％葡萄糖液５００ｍＬ中静脉滴注，ｑｄ，连用１４ｄ。另外５０例（男性３５例，女性１５例；年龄６４±８ａ）以德国进口硝酸异山梨酯注射液２０ｍｇ加入５％葡萄糖液５００ｍＬ中静脉滴注，ｑｄ，连用１４ｄ。结果：国产组临床总有效率为９４．１％，心电图总有效率为４８．０％，进口组则依次为９６％与５２％；组间比较，Ｐ值均＞０．０５。该药尚有扩张血管、降低血压、减低心肌氧耗，改善左室功能等作用。结论：本药的疗效和作用与进口硝酸异山梨酯注射液相近。
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| 关 键 词： | 硝酸异山梨酯 心绞痛 心脏功能试验 心电描记术 静脉内输注 |
Isosorbide dinitrate intravenous infusion in treatment of angina pectoris in 102 patients |
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| XU Ji-Min,HUANG Zhen-Hua,ZHENG Hui-Jun.Isosorbide dinitrate intravenous infusion in treatment of angina pectoris in 102 patients[J].Chinese Journal of New Drugs and Clinical Remedies,1997(1). |
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| Authors: | XU Ji-Min HUANG Zhen-Hua ZHENG Hui-Jun |
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| Abstract: | AIM: To compare the clinical efficacy of domestic and imported isosorbide dinitrate in treatment of angina pectoris. METHODS: One hundred and two patients (M 67, F 35; age 63±s 9 a) of coronary disease with angina pectoris were treated with domestic preparation and 50 patients (M 35, F 15; age 64±8 a) were treated with imported preparation, both were infused 20 mg plus 5% glucose 500 mL, iv, gtt qd for 14 d. RESULTS: The total clinical effective rate was 94.1%, ECG effective rate was 48.0% for domestic group; and 96% and 52% respectively for imported group.The drug dilated blood vessels, reduced blood pressure and myocardial O 2 consumption, and improved left ventricular function. CONCLUTION: The effects of domestic and imported isosorbide dinitrate are similar. |
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| Keywords: | isosorbide dinitrate angina pectoris heart function tests electrocardiography intravenous infusions |
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