丙氨酰胺谷氨酰胺对术后化疗消化道肿瘤患者的作用

目的研究添加丙氨酰胺谷氨酰胺(Ala-Gln)的全胃肠外营养(TPN)对术后化疗消化道肿瘤患者的作用。方法30例消化道肿瘤患者，按序随机分为两组传统组和二肽组，每组15例，术后给予等热量(104.6kJ

Effect of alanyl-glutamine on gastrointestinal cancer patients undergoing postoperative chemotherapy

Objective To study the effect ofalanyl-glutamine(Ala-Gln)supplemented total parenteral nutrition(TPN) on gastrointestinal cancer patients undergoing postoperative chemotherapy. Method Thirty patients receiving postoperative chemotherapy for 5 days were divided into two groups:conventional TPN(control group)and Ala-Gln supplemented group (Ala-Gln group).All patients received isocaloric(104.6kJ.kg-1.d-1)and isnitrogenous(0.16gN.kg-1.d-1) TPN,however,35% of nitrogen was supplied with Ala-Gln in Ala-Gln group.Anthropometric and biochemical parameters were monitored before and after the treatment. Results There were no significant differences between the two groups in anthropometric parameters,serum total protein (TP),albumin (ALB),Prealbumin (PAB),transferrin (TF),total lymphocyte count (TLC),liver function,kidney function and serum lipid parameters.Compared with that on preoperative day,MAC,TF,TLC maintained unchangeablcness on the end of the TPN in Ala-Gln Group (P>0.05),but significantly decreased in control group(P<0.05).By the end of the study cumulated nitrogen balance(CNB)in two groups was (-32.17±10.16)g/5d and (-13.56±5.61)g/5d respectively.There were significant differences in nitrogen balance and CNB between the two groups (P<0.01). Conclusion Ala-Gln supplemented TPN was safe and effective in the patients with postoperative chemotherapy.It attenuated protein catabolism,improve nitrogen balance,maintained total lymphocyte count