| 施图伦滴眼液中化学成分的LC-MS/MS法鉴定 |
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| 引用本文： | 杨保华,何威之,郭雅琦.施图伦滴眼液中化学成分的LC-MS/MS法鉴定[J].医学教育探索,2011,26(2):113-115. |
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| 作者姓名： | 杨保华 何威之 郭雅琦 |
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| 作者单位： | 上海信谊药厂有限公司 药物研究所，上海 201206 |
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| 摘 要： | 目的 建立LC-MS/MS法，对施图伦滴眼液中化学成分进行鉴定。方法 采用HPLC-MS/MS法对各色谱峰进行质谱分析，结合对照品以及水解试验，并参考文献确认各成分。结果 确认了15个成分，其中包括七叶亭苷和14个洋地黄强心苷类成分。结论 该方法快速、灵敏，可为施图伦滴眼液的质量控制及稳定性研究提供依据，为洋地黄化学成分进一步研究提供参考。
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| 关 键 词： | 施图伦滴眼液 七叶亭苷 洋地黄 强心苷 LC-MS |
Identification of chemical constituents in Augentropfen Stulln Mono by LC-MS/MS |
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| YANG Bao-hua and HE Wei-zhi,GUO Ya-qi.Identification of chemical constituents in Augentropfen Stulln Mono by LC-MS/MS[J].Researches in Medical Education,2011,26(2):113-115. |
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| Authors: | YANG Bao-hua and HE Wei-zhi GUO Ya-qi |
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| Institution: | Shanghai Sine Pharmaceutical Co., Ltd., Pharmaceutical R & D Center, Shanghai 201206, China |
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| Abstract: | Objective To establish an LC-MS/MS method for identification of chemical constituents in Augentropfen Stulln Mono. Methods By using HPLC-MS/MS, reference substances, and hydrolysis test, the ingredients were identified according to their molecular weight. Results Fifteen components were identified including esculin and fourteen digitalis cardiac glycosides. Conclusion This method is rapid, sensitive and could be used in quality control and stability study of the product. |
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| Keywords: | Augentropfen Stulln Mono esculin Digitalis purpurea L cardiac glycoside LC-MS |
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