| 通关藤及其制剂的药理作用和临床应用进展 |
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| 引用本文： | 谢丽艳,居文政,周 玲,徐 洁,谈恒山.通关藤及其制剂的药理作用和临床应用进展[J].医学教育探索,2011,26(6):439-443. |
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| 作者姓名： | 谢丽艳 居文政 周 玲 徐 洁 谈恒山 |
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| 作者单位： | 南京中医药大学 药学院，江苏 南京 210029;南京中医药大学附属医院 临床药理科，江苏 南京 210029;南京中医药大学 药学院，江苏 南京 210029;南京军区总医院，江苏 南京 210002 |
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| 基金项目： | 江苏省中医药领军人才项目（LJ200906）；江苏省高校优势学科建设工程资助项目 |
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| 摘 要： | 通关藤含有三萜、甾醇、有机酸等化学成分，其活性成分主要为研究较多的C21甾体类化合物，而对其他成分的研究较少；现代药理研究表明，其具有较强的生物活性，在抗肿瘤、降压、平喘等方面有着显著作用。通关藤经提取制成的一系列药物制剂在临床上已得到广泛应用，其中消癌平注射液治疗癌症疗效较好。对近年来通关藤及其制剂的药理研究和临床应用进行概述，为其进一步研究、开发和临床合理用药提供参考。
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| 关 键 词： | 通关藤 消癌平注射液 抗癌 药理作用 临床应用 |
Advances in pharmacological effects and clinical application of Marsdenia tenacissima and its preparation |
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| XIE Li-yan,JU Wen-zheng,ZHOU Ling,XU Jie and TAN Heng-shan.Advances in pharmacological effects and clinical application of Marsdenia tenacissima and its preparation[J].Researches in Medical Education,2011,26(6):439-443. |
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| Authors: | XIE Li-yan JU Wen-zheng ZHOU Ling XU Jie and TAN Heng-shan |
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| Institution: | School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210029, China;Department of Clinic Pharmacology, the Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China;School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210029, China;General Hospital Forces of Nanjing Military Region, Nanjing 210002, China |
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| Abstract: | Marsdenia tenacissima is a Chinese medicine with antitumor effect, and its chemical compositions include triterpenoids, sterols, organic acids, and so on. The main antitumor active compositions of C21 steroids have been studied more than others. Modern pharmacological studies have shown the strong biological activity and the significant role on the antitumor, blood pressure, asthma and so on. Nowadays M. tenacissima and its preparation have extensive application in clinic. In this paper, pharmacological effects and clinical applications of M. tenacissima and its preparations had been reviewed to provide the theoretical basis for its further research. |
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| Keywords: | Marsdenia tenacissima (Roxb ) Wight et Arn Xiaoaiping Injection antitumor pharmacological effect clinical appliciation |
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