| 龙葵碱对H22荷瘤小鼠肿瘤细胞膜唾液酸和封闭度的影响 |
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| 引用本文： | 季宇彬 王胜惠 高世勇 邹翔 汲晨峰. 龙葵碱对H22荷瘤小鼠肿瘤细胞膜唾液酸和封闭度的影响[J]. 医学教育探索, 2005, 0(1): 79-81 |
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| 作者姓名： | 季宇彬 王胜惠 高世勇 邹翔 汲晨峰 |
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| 作者单位： | 哈尔滨商业大学药物研究所博士后科研工作站 黑龙江哈尔滨150076(季宇彬，王胜惠，高世勇，邹翔)，哈尔滨商业大学药物研究所博士后科研工作站 黑龙江哈尔滨150076(汲晨峰) |
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| 基金项目： | 国家自然科学基金资助项目(30400591)，黑龙江省自然科学基金资助项目(D2004-13)，哈尔滨市青年科学基金资助项目(2004AFQXJ035)。 |
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| 摘 要： | 目的研究龙葵碱对H22荷瘤小鼠肿瘤细胞膜唾液酸(SA)水平和封闭度的影响。方法建立H22荷瘤小鼠模型,荷瘤小鼠分别sc生理盐水、环磷酰胺、龙葵碱(9.375、18.75、37.5mg/kg)。采用比色法测定H22小鼠肿瘤细胞膜SA水平和封闭度。结果龙葵碱可剂量依赖性地降低荷瘤小鼠肿瘤细胞膜SA水平和肿瘤细胞膜封闭度。结论龙葵碱通过降低H22荷瘤小鼠肿瘤细胞膜SA水平和肿瘤细胞膜封闭度起抗肿瘤作用。
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| 关 键 词： | 龙葵碱 H荷瘤小鼠 膜封闭度 唾液酸 |
Effect of Solanum nigrum total alkaloid on sialic acid and blocking degree of tumor cell membrane in H22 tumor-bearing mice |
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| JI Yu-bin,WANG Sheng-hui,GAO Shi-yong,ZOU Xiang,JI Chen-feng. Effect of Solanum nigrum total alkaloid on sialic acid and blocking degree of tumor cell membrane in H22 tumor-bearing mice[J]. Researches in Medical Education, 2005, 0(1): 79-81 |
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| Authors: | JI Yu-bin WANG Sheng-hui GAO Shi-yong ZOU Xiang JI Chen-feng |
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| Abstract: | Objective To study the effects of total alkaloid from Solanum nigrum (TASN) on sialic acid (SA) and blocking degree of tumor cell membrane in H_(22) tumor-bearing mice. Methods H_(22) tumor-bearing mice model was established and H_(22) tumor-bearing mice were given NS, Cytoxan (CTX), and TASN (9.375, 18.75, and 37.5 mg/kg) by sc, respectively. SA content and blocking degree of tumor cell membrane in H_(22) mice were determined by chromatometry. Results TASN could decrease the SA content and the blocking degree of tumor cell membrane in H_(22) tumor-bearing mice in a dose-dependent manner. Conclusion TASN shows the antitumor activity through decreasing the SA content and blocking degree of tumor cell membrane in H_(22) tumor-bearing mice. |
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| Keywords: | total alkaloid of Solanum nigrum L. (TASN) H_(22) tumor-bearing mice blocking degree of membrane sialic acid (SA) |
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