氧化低密度脂蛋白致血管内皮损伤机制及中药复方防治的研究进展

低密度脂蛋白经氧化修饰后主要通过凝集素样氧化低密度脂蛋白受体-1导致管内皮细胞损伤，诱导黏附分子和炎症因子的合成与释放，加重血管炎症反应，诱导内皮细胞凋亡，进而导致动脉粥样硬化等心血管疾病。中药复方通过抑制低密度脂蛋白(LDL)氧化生成氧化低密度脂蛋白（OX-LDL），防治血管内皮损伤，进而防治动脉粥样硬化的发生与发展。综述近年来有关OX-LDL损伤血管内皮细胞功能的机制，及具有抗OX-LDL损伤作用的、脑心通、冠心合剂、血脉脂康胶囊、通心络、六味地黄方,黄连解毒汤等中药复方的研究进展。

Advances in studies on mechanisms of oxidized low density lipoprotein-induced endothelial dysfunction and its prevention by Chinese medicinal formulae

Oxidized low density lipoprotein (OX-LDL) results the endothelial damage via lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) inducing the synthesis and release of adhesion molecules and proinflammatory cytokines, aggravating the vascular inflammation, and causing the endothelial cells apoptosis so as to lead atherosclerosis and some other cardiovascular diseases. Chinese medicinal formulae could prevent the endothelial injury by inhibiting that low density lipoprotein (LDL) was oxidized to OX-LDL, so as to block the occurance and development of atherosclerosis. The recent progress in research on the mechanism of OX-LDL-induced endothelial cell dysfunction and the related Chinese Traditional Medical Formulae with anti-OX-LDL function, such as Naoxintong, Guanxin Decoction, Xuemaizhikang Capsula, Tongxinluo, Liuwei Dihuang, and Huanglian Jiedu Decoction etc.