甘草及其活性成分抗炎与抗炎机制的研究进展

甘草及其活性成分能提高吞噬细胞的吞噬功能、调节淋巴细胞数量与功能、抑制IgE抗体形成、抗炎症介质及前炎性细胞因子，具有抗炎、抗变态反应的药理活性。甘草黄酮类化合物（异甘草素、异甘草苷、甘草素、甘草查耳酮A、光甘草定、甘草醇等）、甘草多糖和甘草酸是其抗炎、抗变应性炎症的活性成分。其中对异甘草素、甘草查耳酮A和甘草酸的抗炎及抗变应性炎症作用的研究较为深入。综述甘草及其活性成分的抗炎作用及抗炎机制的研究进展。

Advances in studies on Glycyrrhizae Radix et Rhizoma and its active components in anti-inflammation and mechanism

Glycyrrhizae Radix et Rhizoma and its active components can enhance the phagocytic function of phagocytes, modulate the quantity and function of lymphocytes, inhibit the antibody formation of IgE, possess the effects against inflammatory mediator and proinflammatory cytokines, and induce pharmacologic activities against inflammation and allergy. Flavonoids (isoliquiritigenin, isoliquiritin, liquiritigenin, licochalcone A, glabridin, glycyrol, and so on), glycyrrhiza polysaccharide and glycyrrhizic acid are active components of Glycyrrhizae Radix et Rhizoma on anti-inflammation and immunoregulation. Among others, the anti-inflammation and anti-allergy of isoliquiritigenin, licochalcone A and glycyyrrhizic acid are studied more profoundly. Research advances on the anti-inflammation and mechanism of Glycyrrhizae Radix et Rhizoma and its active components are reviewed in this paper.