| 气相色谱—质谱联机分离鉴定叶枯灵的代谢物 |
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| 引用本文： | 王宇 高宁. 气相色谱—质谱联机分离鉴定叶枯灵的代谢物[J]. 现代预防医学, 1992, 19(4): 193-194 |
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| 作者姓名： | 王宇 高宁 |
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| 作者单位： | 华西医科大学药学院新药设计研究所，华西医科大学药学院新药设计研究所，第三军医大学卫防系环境卫生学教研究室 华西医科大学制药厂 |
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| 基金项目： | “七.五”国家科技攻关项目 |
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| 摘 要： | 经口灌胃给大鼠叶枯灵35.8mg/kg,收集24小时尿,采用气相色谱—质谱(GC—MS)联机分离和鉴定了尿中的主要代谢物。据此推断,叶枯灵进入体内迅速水解,继而在氮原子上乙酰化,并用化学合成品对照确证,该法灵敏度高,分离效果好。
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| 关 键 词： | 叶枯灵 代谢物 GC－MS |
ISOLATION AND IDENTIFICATION OF METABOLITES OF YEKULING BY GASCHROMATOGRAPHIC-MASS SPECTROMETRY |
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| Wang Yu Research Center of Drug Design,WCUMS.. ISOLATION AND IDENTIFICATION OF METABOLITES OF YEKULING BY GASCHROMATOGRAPHIC-MASS SPECTROMETRY[J]. Modern Preventive Medicine, 1992, 19(4): 193-194 |
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| Authors: | Wang Yu Research Center of Drug Design WCUMS. |
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| Abstract: | Rats were given. 35.8mg/kg of yekuling orally and urine was collected 24 hours later.The main metabolites in the urine were isolated and identified by GC-MS. It may be considered that Yekuling was readily hydrolyzed to Benzoic acid and 1.3-dithiolan-2-ylidene-hydrazine in rat, after which 1.3-dithiolan-2-ylidenehydrazine was acetylated at the nitrogenatom. Then the presence of these metabolites was further confirmed by chemical synthesiS. The sensitivity and isolation are good. |
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| Keywords: | Yekuling Metabolites GC-MS |
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