| 镰形棘豆总生物碱对S180荷瘤小鼠的抗肿瘤作用研究 |
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| 引用本文： | 陈醒,杨光明,何媛媛,蔡宝昌. 镰形棘豆总生物碱对S180荷瘤小鼠的抗肿瘤作用研究[J]. 中华中医药杂志, 2011, 0(11): 2540-2542 |
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| 作者姓名： | 陈醒 杨光明 何媛媛 蔡宝昌 |
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| 作者单位： | 南京中医药大学江苏省中药炮制重点实验室国家中医药管理局中药炮制标准重点研究室国家教育部中药炮制规范化及标准化工程研究中心; |
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| 基金项目： | 国家自然科学基金项目(No.30902012)~~ |
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| 摘 要： | 目的:研究镰形棘豆总生物碱的体内抗肿瘤作用并探讨其作用机制。方法:采用S180荷瘤小鼠模型,将生理盐水和总生物碱灌胃给药,阳性药环磷酰胺腹腔注射,给药后检测小鼠的体质量、抑瘤率、胸腺指数以及脾指数,并通过HE染色,光镜下观察肿瘤细胞的形态变化。结果:镰形棘豆总生物碱高、中、低剂量组对S180荷瘤小鼠的抑瘤率分别为74.8%、79.3%、69.4%,总生物碱各剂量组对S180荷瘤小鼠的胸腺指数和脾指数均高于环磷酰胺组和生理盐水组,但无显著性差异。实验过程中,小鼠体质量没有降低,未显示任何毒性反应。HE染色发现,给药组肿瘤间质可见炎细胞浸润。结论:镰形棘豆总生物碱具有明显的抗肿瘤作用,其机制可能是通过增强小鼠的免疫调节功能来实现的。
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| 关 键 词： | 镰形棘豆 生物碱 抗肿瘤 |
Antitumor effect of alkaloids from Oxytropis falcata on S180 bearing mice |
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| CHEN Xing,YANG Guang-ming,HE Yuan-yuan,CAI Bao-chang. Antitumor effect of alkaloids from Oxytropis falcata on S180 bearing mice[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2011, 0(11): 2540-2542 |
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| Authors: | CHEN Xing YANG Guang-ming HE Yuan-yuan CAI Bao-chang |
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| Affiliation: | CHEN Xing,YANG Guang-ming,HE Yuan-yuan,CAI Bao-chang(Nanjing University of Chinese Medicine,Jiangsu Key Laboratory of Chinese Medicine Processing,Key Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing,Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing,Nanjing 210029,China) |
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| Abstract: | Objective: To study the antitumor effect of alkaloids from Oxytropis falcata in mice with further inquiry into the possible mechanism.Methods: The S180 bearing mice were prepared and treated with NS and total alkaloids by ig,with CTX by ip.After 10 days' administration,body weight,tumor weight,thymus index and spleen index of the mice were observed and calculated.Results: The tumor inhibition rates of high,moderate and low dosage of total alkaloids were 74.8%,79.3% and 69.4%.The thymus index and spleen inde... |
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| Keywords: | Oxytropis falcata Bunge Total alkaloids Antitumor |
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