| 菩人丹超微粉对糖尿病大鼠视网膜碱性成纤维细胞因子表达的影响 |
| |
| 引用本文： | 董志军,王海彬,庞宗然,张铁民. 菩人丹超微粉对糖尿病大鼠视网膜碱性成纤维细胞因子表达的影响[J]. 中华中医药杂志, 2011, 0(12): 2971-2973 |
| |
| 作者姓名： | 董志军 王海彬 庞宗然 张铁民 |
| |
| 作者单位： | 承德医学院附属医院眼科;中央民族大学中国少数民族医学研究院; |
| |
| 摘 要： | 目的:探讨菩人丹超微粉对糖尿病大鼠视网膜碱性成纤维细胞因子(bFGF)表达的影响。方法:48只Wistar大鼠随机分为4组,正常对照组、糖尿病模型组(模型组)、菩人丹超微粉治疗组(菩人丹组)和导升明组,每组12只。糖尿病模型组、菩人丹超微粉治疗组和导升明组大鼠均采用链脲佐菌素(STZ)连续腹腔注射建立2型糖尿病大鼠模型。模型成功建立后,菩人丹超微粉治疗组大鼠给予菩人丹超微粉灌胃,导升明组大鼠给予导升明灌胃,时间均为3个月。采用SP免疫组织化学染色法、Western blot法检测视网膜bFGF蛋白的表达;逆转录聚合酶链反应(RT-PCR)检测视网膜bFGF mRNA的表达。结果:糖尿病模型组与正常对照组比较,大鼠视网膜bFGF蛋白及mRNA表达均明显升高(P<0.01),菩人丹超微粉治疗组、导升明组与糖尿病模型组比较,大鼠视网膜bFGF蛋白及mRNA表达均明显降低(P<0.01);且菩人丹超微粉治疗组与导升明组比较无明显差别。结论:菩人丹超微粉可通过下调bFGF表达,抑制病理性新生血管生成,发挥对糖尿病视网膜损伤的保护作用。
|
| 关 键 词： | 菩人丹 超微粉 糖尿病视网膜病变 碱性成纤维细胞因子 大鼠 |
Effects of Purendan superfine powder on expression of retinal basic fibroblast growth factor in diabetic rat |
| |
| DONG Zhi-jun,WANG Hai-bin,PANG Zong-ran,ZHANG Tie-min. Effects of Purendan superfine powder on expression of retinal basic fibroblast growth factor in diabetic rat[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2011, 0(12): 2971-2973 |
| |
| Authors: | DONG Zhi-jun WANG Hai-bin PANG Zong-ran ZHANG Tie-min |
| |
| Affiliation: | DONG Zhi-jun1,WANG Hai-bin1,PANG Zong-ran2,ZHANG Tie-min1(1Department of Ophthalmology,Affiliated Hospital of Chengde Medical College,Chengde 067000,China,2Institute of Chinese Minority Traditional Medicine,Minzu University of China,Beijing 100081,China) |
| |
| Abstract: | Objective: To investigate the effects of Purendan superfine powder(PRD) on retinal basic fibroblast growth factor(bFGF) expression in diabetic rat.Methods: 48 male Wistar rats were randomly divided into 4 groups(n=12): normal control group,diabetes model group,PRD treatment group and Doxium group.The diabetes model rats were made by continuous intraperitoneal injection of Streptozotocin(STZ).After the diabetes animal model was successfully established,the rats in PRD treatment group and Doxium group were re... |
| |
| Keywords: | Purendan Superfine powder Diabetic retinopathy Basic fibroblast growth factor Rat |
| 本文献已被 CNKI 等数据库收录！ |
|
