| 中药外用制剂皮肤过敏动物实验模型及评价指标研究探讨 |
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| 引用本文： | 郑智音,贾晓斌,舒娈,朱静,谭晓斌,刘文博.中药外用制剂皮肤过敏动物实验模型及评价指标研究探讨[J].中华中医药杂志,2011(12):2929-2933. |
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| 作者姓名： | 郑智音 贾晓斌 舒娈 朱静 谭晓斌 刘文博 |
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| 作者单位： | 江苏省中医药研究院国家中医药管理局中药释药系统重点研究室;江苏大学药学院; |
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| 基金项目： | 国家“十一五”科技支撑计划项目(No.2008BAI53B072); 江苏省中医药领军人才项目(2006)~~ |
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| 摘 要： | 药物在使用过程中具有两重性:治疗作用和副作用。中药外用制剂的安全性通常较口服和注射剂高,而容易被忽视其副作用,尤其是中药外用制剂临床前安全性评价中,对其致敏性问题,目前研究的较少。通过查阅国内外相关文献,对国内常用的豚鼠背部模型和小鼠耳廓模型及评价指标,进行系统总结、分析,找出存在的问题。同时,借鉴国外研究者研究用小型猪耳廓模型和猴背部模型,综合其优缺点,探讨适用于提高外用制剂过敏反应评价准确性的动物实验方法。以期为中药外用制剂临床前安全性评价提供参考,为减少中药外用制剂过敏反应的发生提供借鉴。同时,希望引起有关专家和学者对中药外用制剂引发皮肤过敏反应这一问题的重视。
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| 关 键 词： | 中药 外用制剂 过敏 动物实验模型 评价指标 |
Analysis of animal models and index of skin allergy caused by external preparation of Chinese medicine |
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| ZHENG Zhi-yin,JIA Xiao-bin,SHU Luan,ZHU Jing,TAN Xiao-bin,LIU Wen-bo.Analysis of animal models and index of skin allergy caused by external preparation of Chinese medicine[J].China Journal of Traditional Chinese Medicine and Pharmacy,2011(12):2929-2933. |
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| Authors: | ZHENG Zhi-yin JIA Xiao-bin SHU Luan ZHU Jing TAN Xiao-bin LIU Wen-bo |
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| Institution: | ZHENG Zhi-yin1,2,JIA Xiao-bin1,SHU Luan1,ZHU Jing1,TAN Xiao-bin1,LIU Wen-bo1(1Key Laboratory of SATCM Drug Delivery System of Chinese Meteria Medica,Jiangsu Province Academy of TCM,Nanjing 210028,China,2College of Pharmacy,Jiangsu University,Zhenjiang 212013,China) |
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| Abstract: | Drug has a dual nature during use: therapeutic effects and side effects.The safety property of Chinese herb external preparations are usually higher than oral and injection preparations,it is easier to ignore its side effects,especially before we used,we don't know whether it will induce our skin allergy or not.Currently,there are few studies on how to predict the safety of external preparations.After read lots of domestic and foreign literatures,this study summarized a feasibility animal test program which... |
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| Keywords: | Chinese medicine External preparation Allergy Animal experment model Evaluation index |
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