| 基于动物行为学考察萸黄连“反制”前后的药性差异研究 |
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| 引用本文： | 蒋俊,贾晓斌,李平,徐江,周成林,蔡宝昌,吴皓.基于动物行为学考察萸黄连“反制”前后的药性差异研究[J].中华中医药杂志,2011(12):2974-2976. |
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| 作者姓名： | 蒋俊 贾晓斌 李平 徐江 周成林 蔡宝昌 吴皓 |
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| 作者单位： | 江苏省中医药研究院中药新型给药系统重点实验室国家中医药管理局中药口服释药系统重点研究室;镇江出入境检验检疫局国家食品添加剂及调味品检测重点实验室;南京中医药大学江苏省中药炮制重点实验室; |
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| 基金项目： | 江苏省中药炮制重点实验室开放课题(No.ZYPZ002); 江苏省中医药领军人才专项(2006)~~ |
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| 摘 要： | 目的:研究萸黄连"反制"前后的寒热药性的差异性。方法:选用KM小鼠,依据动物行为趋向性,分别给予黄连、吴茱萸、萸黄连,考察不同药物对小鼠温度趋向性的影响,并结合测定小鼠肝脏ATP酶的活力,探讨不同药性药物对小鼠机体能力代谢的影响。结果:吴茱萸组小鼠体现出"趋寒性",能使小鼠ATP酶活性增强;黄连和萸黄连组小鼠体现出"趋热性",并抑制小鼠ATP酶活性;黄连组和萸黄连组相比,黄连组小鼠的"趋热性"较萸黄连组强(P<0.05),萸黄连组小鼠的钠钾ATPase活力较黄连组有显著提高(P<0.05);结论:吴茱萸体现出"热性",黄连和萸黄连均体现出"寒性",但萸黄连与黄连相比,"寒性"降低。此结论与萸黄连"以热制寒"的"反制"传统炮制理论相符。
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| 关 键 词： | 萸黄连 反制 动物行为学 趋向性 ATP酶 能量代谢 |
Study on the difference of drug-nature of Fructus Evodiae Rutaecarpae processed Coptis chinensis based on laboratory animals praxiology |
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| Institution: | JIANG Jun1,2,JIA Xiao-bin1,3,LI Ping2,XU Jiang2,ZHOU Cheng-lin2,CAI Bao-chang3,WU Hao3(1Key Laboratory of New Drug Delivery System of Chinese Meteria Medica,Jiangsu Provincial Academy of Chinese Medicine,key laboratory of Drug Delivery System of SATCM,Nanjing 210028,China,2State Key Laboratory of Food Additive and Condiment Testing,Zhenjiang Entry-Exit Inspection and Quarantine Bureau,Zhenjiang 212008,3Key Laboratory of Processing of Chinese Materia Medica,Nanjing University of Chinese Medicine,Nanjin... |
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| Abstract: | Objective: Study on the difference of drug-nature of Fructus Evodiae Rutaecarpae processed Coptis chinensis based on praxiology of laboratory animals.Methods:KM mice was adopted,and they were administed Rhizoma Coptidis,Fructus Evodiae Rutaecarpae,and Fructus Evodiae Rutaecarpae processed Coptis chinensis,respectively.Temperature tendency,vitality of ATP enzyme in liver were determinated to research the different effects of different drugs to energy metabolism.Results: All the mice in Fructus Evodiae Rutaec... |
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| Keywords: | Fructus Evodiae Rutaecarpae processed Coptis chinensis Clash process Ethology Praxiology ATP enzyme Energy metabolism |
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