| 茵陈蒿汤调节高脂饮食诱导大鼠脂质代谢紊乱的作用机制 |
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| 引用本文： | 林曼婷,范应,陈少东,徐维佳,周海虹,李晶,刘益华.茵陈蒿汤调节高脂饮食诱导大鼠脂质代谢紊乱的作用机制[J].中华中医药杂志,2011(10):2428-2430. |
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| 作者姓名： | 林曼婷 范应 陈少东 徐维佳 周海虹 李晶 刘益华 |
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| 作者单位： | 厦门大学医学院中医系; |
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| 基金项目： | 福建省自然科学基金青年科技人才创新项目(No.2009J05089); 厦门市重大科技计划项目(No.3502Z20100006); 厦门大学医学院院长基金项目~~ |
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| 摘 要： | 目的:探讨经方茵陈蒿汤调节高脂饮食诱导大鼠脂质代谢紊乱的作用机制。方法:将18只雄性SD大鼠随机分成正常组、模型组和茵陈蒿汤组,模型组和茵陈蒿汤组给予高脂饮食喂养10周,茵陈蒿汤组第6周起给予茵陈蒿汤灌胃5周。10周后处死大鼠,收集标本,检测血清甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、胆固醇(Ch)含量,肝组织TG含量,对肝脏组织进行HE染色。结果:茵陈蒿汤明显降低模型大鼠血清TG、LDL-C、Ch含量,增加血清HDL-C含量,显著降低肝脏TG含量,改善肝组织脂质沉积的病理状态。结论:茵陈蒿汤能够有效的调节高脂饮食诱导的大鼠血清和肝组织脂质代谢紊乱,其机制可能是促进HDL-C合成,减少Ch、TG、LDL-C在体内的蓄积。
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| 关 键 词： | 茵陈蒿汤 高脂血症 脂质代谢紊乱 脂肪肝 |
Effect and mechanism of Yinchenhao Decoction in preventing lipid metabolic disturbance for rats fed on high fat diet |
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| LIN Man-ting,FAN Ying,CHEN Shao-dong,XU Wei-jia,ZHOU Hai-hong,LI Jing,LIU Yi-hua.Effect and mechanism of Yinchenhao Decoction in preventing lipid metabolic disturbance for rats fed on high fat diet[J].China Journal of Traditional Chinese Medicine and Pharmacy,2011(10):2428-2430. |
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| Authors: | LIN Man-ting FAN Ying CHEN Shao-dong XU Wei-jia ZHOU Hai-hong LI Jing LIU Yi-hua |
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| Institution: | LIN Man-ting,FAN Ying,CHEN Shao-dong,XU Wei-jia,ZHOU Hai-hong,LI Jing,LIU Yi-hua(TCM Department of Medical College of Xiamen University,Xiamen 361005,China) |
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| Abstract: | Objective: To study the protective mechanism of Yinchenhao Decoction by its modulating lipid disturbance.Methods: Total 18 male SD rats were divided into control group,model group and Yinchenhao Decoction group randomly.Rats in model and Yinchenhao Decoction group were fed with high cholesterol and high fat forage for 10 weeks to reproduce lipid disturbance model,in the meantime,rats in Yinchenhao Decoction group were given with Yinchenhao Decoction.All rats were sacrificed at the 10 weeks and samples were ... |
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| Keywords: | Yinchenhao Decoction Hyperlipemia Lipid disturbance NAFLD |
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