辛伐他汀对2型糖尿病患者血管内皮功能及炎症因子的影响

目的观察辛伐他汀对2型糖尿病患者血管内皮功能及炎症因子的影响。方法选择30例2型糖尿病（T2DM）患者及25例对照者，给予辛伐他汀20mg／d治疗12个月。分别于治疗前、治疗1个月及12个月时，检测肱动脉血流介导性扩张，并测定主要血脂参数、超敏C反应蛋白（hsCRP）、空腹血糖（FPG）、胰岛素（Flns）和胰岛素抵抗指数（HOMA-IR）。结果①辛伐他汀治疗可明显改善T2DM组及对照组患者血脂水平。②辛伐他汀治疗1个月后.T2DM组患者肱动脉内皮依赖性舒张功能（FMD）较治疗前无明显变化（5.94±0.87）％vs.（5.65±0.65）％，P〉0.05]，治疗12个月后，FMD虽有上升趋势（6.10±0.71）％]，但仍无显著性差异。辛伐他汀可明显改善对照组的FMD。③治疗12个月时T2DM组患者血清hs-CRP水平由（15.21±3.71）mg／L降至（10.51±2.90）mg/L（P〈0.01）。④辛伐他汀对T2DM患者FPG、Fins及HOMA-IR均无影响。结论辛伐他汀治疗12个月，尽管可以显著降低T2DM患者血脂水平，减轻炎症反应.但受损的血管内皮功能并未得到改善。

The effects of simvastatin therapy on endothelial function and inflammatory factor in type 2 diabetes mellitus without cardiovascular disease

Objective To investigate the effects of simvastatin on vascular endothelial function and hypersensitivity C-reactive protein(hs-CRP) in patients with type 2 diabetes mellitus(T2DM).Methods A total of 32 T2DM patients and 25 control subjects received the treatment of 20 mg/d simvastatin for 12 months.Endothelial dependent flow-mediated vasodilation(FMD) was assessed at baseline,after 1 month and 12 months of simvastatin therapy.Serum lipid profiles,hs-CRP,fasting glucose(FPG),fasting insulin(FIns) and homeos...