四君子汤对脾虚患者血清可溶性细胞粘附分子-1水平和单核细胞功能的影响 |
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引用本文: | 章梅,张仲海,夏天,王宗仁,孙凯,徐重明,于文彬.四君子汤对脾虚患者血清可溶性细胞粘附分子-1水平和单核细胞功能的影响[J].中国中西医结合杂志,1999,19(5):270-272. |
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作者姓名: | 章梅 张仲海 夏天 王宗仁 孙凯 徐重明 于文彬 |
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作者单位: | |
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摘 要: | 目的:观察四君子汤对脾虚患者血清可溶性细胞粘附分子-1(sICAM 1)和单核细胞功能的影响。方法:采用酶联免疫吸附法和改良噻唑蓝法对66例脾虚患者血清sICAM 1和白细胞介素 15(IL 15)及单核细胞抗体依赖性细胞介导的细胞毒反应(ADCC)进行检测。结果:脾虚患者血清sICAM 1水平升高,IL 15分泌减少,ADCC功能下降,表现为免疫功能低下,经过四君子汤治疗后,上述指标恢复正常。结论:四君子汤健脾益气可提高机体免疫功能
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关 键 词: | 脾虚患者 四君子汤 可溶性细胞粘附分子-1 白细胞介素-15 抗体依赖性细胞介导的细胞毒反应 |
Effect of Sijunzi Decoction on Serum Soluble Intercellular Adhesive Molecule 1, Interleukin 15 and Monocyte Antibody Dependent Cell Mediated Cytotoxicity in Patients of Spleen Deficiency |
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Abstract: | Objective: To study the effect of Sijunzi Decoction (SJZD) on serum soluble intercellular adhesive molecule 1 (sICAM 1), interleukin 15 (IL 15) and monocyte antibody dependent cell mediated cytotoxicity (ADCC) in patients of Spleen Deficiency. Methods: Serum sICAM 1, IL 15 and monocyte ADCC of 66 Spleen Deficiency patients were determined by enzyme linked immunosorbent assay and modified thiazole blue test. Results: Serum sICAM 1 of Spleen Deficiency patients increased, IL 15 secretion decreased and monocyte ADCC function reduced, which displayed as lowered immune function. After SJZD treatment, all the above mentioned parameters were normalized. Conclusion: SJZD could enhance immune function of organism by strengthening Spleen and tonifying Qi. |
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Keywords: | patient of Spleen Deficiency Sijunzi Decoction soluble intercellular adhesive molecule 1 interleukin 15 antibody dependent cell mediated cytotoxicity |
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