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Prognostic significance of cell surface markers in childhood acute lymphoblastic leukaemia.
Authors:S Kumar  T F Carr  D I Evans  P Morris-Jones  I M Hann
Abstract:Examination of surface markers on leukaemic blasts from 51 children with ALL revealed that ALL is a heterogeneous disease. The majority (68%) of patients with ALL lack surface markers (null leukaemia); 28% could be classed as T cell as they form rosettes with sheep RBC and 4% have been shown to possess surface immunoglobulins and hence are classed as B cells. The children with null cell leukaemia have a better prognosis than T and B cell types.
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