| 盐酸维拉帕米口服渗透泵制剂释药特性的研究 |
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| 引用本文： | 叶琳琳,胡宇华,陈军,马建国,丁富新. 盐酸维拉帕米口服渗透泵制剂释药特性的研究[J]. 中国医药工业杂志, 2002, 33(12): 590-592,597 |
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| 作者姓名： | 叶琳琳 胡宇华 陈军 马建国 丁富新 |
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| 作者单位： | 1. 清华大学化工系生物化工研究所
2. 中惠药业有限公司,北京,100084 |
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| 摘 要： | 以盐酸维拉帕米为模型药物，制备了口服渗透泵片，通过考察渗透泵片体外释药各过程的速率，研究口服渗透泵制剂释药的基本过程及其特性，结果表明盐酸维拉帕米口服渗透泵制剂的释药过程主要包括四个步骤，其中体外释药速率与由水渗透过膜过程所控制的药物释放速率接近，从而说明水渗透过膜是控速步骤。
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| 关 键 词： | 盐酸维拉帕米 渗透泵 体外释放 控缓释制剂 |
| 文章编号： | 1001-8255(2002)12-0590-04 |
Study on Delivery Characteristics of Oral Osmotic Pump System of Verapamil Hydrochloride |
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| YE Lin-Lin,HU Yu-Hua,CHEN Jun,MA Jian-Guo,DING Fu-Xin. Study on Delivery Characteristics of Oral Osmotic Pump System of Verapamil Hydrochloride[J]. , 2002, 33(12): 590-592,597 |
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| Authors: | YE Lin-Lin HU Yu-Hua CHEN Jun MA Jian-Guo DING Fu-Xin |
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| Affiliation: | YE Lin-Lin1,HU Yu-Hua1,CHEN Jun2,MA Jian-Guo2,DING Fu-Xin1 |
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| Abstract: | The main processes of the drug delivery of oral osmotic pump system were studied to investigate its delivery characteristics, with verapamil hydrochloride as the model drug. The results showed that the delivery process of the oral osmotic pump system of verapamil hydrochloride mainly included four steps, and the in vitro delivery rate of the oral osmotic pump system was close to the rate controlled by the step of infiltration of water through the membrane, the latter being the control step for this system. |
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| Keywords: | verapamil hydrochloride osmotic pump in vitro release controlled delivery |
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