乳腺肿块的能量多普勒血流定量与病理微血管定量相关性研究

目的　研究超声造影及能量多普勒技术测定乳腺肿瘤的彩色象素密度与病理微血管密度的相关性。方法　应用超声造影和能量多普勒技术观察 5 1例乳腺肿块血流信号 (2 8例良性 ,2 3例恶性 ) ,计算机辅助测量肿瘤血流的彩色象素密度 ,对手术标本进行抗CD3 4因子免疫组化染色测量肿瘤微血管密度。结果　彩色象素密度及微血管密度值均表现为同样梯度 ,即恶性组 >良性组 >对照组 (10例远离肿块的周围乳腺组织 )。恶性组中腋下淋巴结转移组的彩色象素密度及微血管面密度均高于无腋下淋巴结转移组 (P <0 .0 5 )。能量多普勒测定的彩色象素密度与病理微血管面密度有较好的相关性 (r =0 .84,P<0 .0 0 1)。结论　能量多普勒血流定量测值与肿瘤微血管密度测值相关性较好 ,能量多普勒超声造影对乳腺肿瘤的鉴别诊断及乳癌预后的评估有帮助

Correlation between Contrast-Enhanced Power Doppler and Pathology in Quantitative Vascularity of Breast Masses

Purpose To determine the relationship between color pixel density of breast masses in contrast enhanced power Doppler and in pathology. Methods Contrast enhanced power Doppler was performed on 51 patients with breast masses (28 benign, 23 malignant). Computer assisted analyzed color pixel density of breast mass. Microvessel density was measured in surgical specimens after immunohistochemical staining using anti factor CD34. Results Both color pixel density and microvessel density had the same gradient, malignant group>benign group>control group (10 parenchyma distal to breast masses). Axillary node positive tumors demonstrated significantly higher color pixel density and area density of microvessel than did axillary node negative tumors ( P < 0.05 ). These studies showed a good correlation between color pixel density by power Doppler imaging and area density of microvessel by histologic examination ( r =0.84, P <0.001). Conclusion Breast mass vascularity of quantified contrast enhanced power Doppler shows a good correlation with the corresponding histologic microvessel density measurement. Contrast enhanced power Doppler has a potential ability for differentiating breast mass and for predicting breast tumor prognosis.