男性青少年性腺功能减退症患者短期雄激素替代治疗对血脂和hsCRP水平的影响

目的 探讨性腺功能低减的青少年男性，短期雄激素替代治疗对血脂和超敏C反应蛋白（hsCRP）的影响。方法 本研究为前瞻性自身对照研究，共纳入33例性腺功能减退青少年男性。行短期（9个月）雄激素替代治疗，比较治疗前后血睾酮水平、第二性征发育程度、身高、握力、血红蛋白、血脂和hsCRP的差异。结果 （1）替代治疗后，睾酮水平明显升高，第二性征明显发育，身高、握力、血红蛋白显著增加（P值均〈0.05）；（2）短期雄激素替代治疗后，总胆固醇（TC），低密度脂蛋白（LDL-c），高密度脂蛋白（HDL-c）和甘油三酯（TG）部有所下降，但无统计学差异（P〉0．5）。超敏CRP显著下降（P=0.025）。结论 （1）性腺功能低减的青少年男性，短期雄激素替代治疗，可以促进第二性征发育，增加身高、握力和血红蛋白；（2）短期雄激素替代治疗，对血脂无显著性影响。但是，可以使hsCRP明显下降。

The effect of androgen replacement therapy in hypogonadal young male patients on serum lipid profile and hsCRP level

Objective To investigate the effect of short period of androgen replacement therapy in hypogonadal young male patients on serum lipid profile and high sensitive C-reactive protein (hsCRP) level. Methods It was a prospective and self-comparison designed study which recruited in 33 hypogonadal young male patients. The parameters of serum testosterone, penile growth, height, hand wrest strength, hemoglobin, lipid profile and hsCRP before and after androgen replacement treat- ment were compared. Results (1) The serum testosterone, penile growth, height, hand wrest strength, and hemoglobin were increased after androgen replacement (P<0.05). (2) The level of total cholesterol, LDL-c, HDL-c and triglyceride were all decreased but with no significance (P>0.05). The level of hsCRP was significantly reduced (P=0.025). Conclusion (1) Short period of androgen replacement therapy in hypogonadal young male patients could increase the penile growth, height, hand wrest strength and hemoglobin. (2) Such androgen replacement therapy had no significant effect on lipid profile, but could significant reduce the level of hsCRP.