七氟醚、丙泊酚及七氟醚复合丙泊酚维持麻醉对缺血再灌注心肌功能的影响

目的：探讨七氟醚、丙泊酚及七氟醚复合丙泊酚维持麻醉对缺血再灌注心肌功能的影响。方法随机收集2011年3月—2014年2月该院接受二尖瓣膜置换术的患者，随机分为：七氟醚组、丙泊酚组和七氟醚复合丙泊酚组。对比3组血浆c Tn I、CK-MB水平。结果七氟醚组、丙泊酚组和七氟醚复合丙泊酚组在麻醉诱导前血浆c Tn I、CK-MB水平无差异(P>0.05)；主动脉开放后2 h、主动脉开放后4 h、主动脉开放后8 h时，七氟醚组的c Tn I、CK-MB水平明显低于七氟醚组和七氟醚复合丙泊酚组(P<0.05)。结论该次研究认为在二尖瓣瓣膜置换术时采用七氟醚全程吸入麻醉能够明显减少心肌缺血再灌注损伤，值得临床推广。

Effect of Sevoflurane,Propofol and Sevoflurane Combined with Propofol Maintained Anesthesia on Function of Myocardia on Ischemia-Reperfusion

Objective To discuss the effect of sevoflurane, propofol and sevoflurane combined with propofol maintained anesthesia on function of myocardia on Ischemia-reperfusion. Methods The patients receiving mitral valve replacement treated in our hospital from March 2011 to February 2014 were collected and randomly divided into the sevoflurane group, the propofol group and the sevoflurane combined with propofol group, the plasma c Tn I,CK-M levels of the three groups were compared. Results There was no difference in the plasma c Tn I,CK-M levels before anesthesia induction between the three groups, (P>0.05), the c Tn I,CK-MB levels in the sevoflurane group were obviously lower than those in the propofol group and the sevoflurane combined with propofol group (P<0.05)at 2 h, 4 h and 8h after aorta declamping, (P<0.05). Conclusion Adopting sevoflurane full inhalation anesthesia in mitral valve replacement can obviously reduce the cardiac reperfusion injury, which is worth promoting in clinic.