Single-dose pharmacokinetics of fluphenazine after fluphenazine decanoate administration |
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| Authors: | G M Simpson K G Yadalam D F Levinson M J Stephanos E S Lo T B Cooper |
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| Affiliation: | Department of Psychiatry, Medical College of Pennsylvania, Eastern Pennsylvania Psychiatric Institute, Philadelphia 19129. |
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| Abstract: | Fluphenazine decanoate is commonly used as part of maintenance treatment of schizophrenia, but its pharmacokinetics are poorly understood. We administered a single intramuscular dose of fluphenazine decanoate to nine patients and found that plasma fluphenazine level did not decline to 50% of the peak level by day 26 in any of the patients. This means that it has a long half-life measurable in months rather than weeks. |
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