| 应用全胚胎体外培养技术检测高热的胚胎毒性 |
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| 引用本文： | 邹积艳,赵怡璇,李守柔,刘英. 应用全胚胎体外培养技术检测高热的胚胎毒性[J]. 吉林大学学报(医学版), 1999, 25(4): 431-432 |
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| 作者姓名： | 邹积艳 赵怡璇 李守柔 刘英 |
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| 作者单位： | 1. 第二临床学院妇产科，长春 130041
2. 白求恩医大药厂 |
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| 摘 要： | 目的：研究高热对胚胎发育的影响。方法：采用全胚胎体外培养技术。结果：在一同作用时间，温度升至４０℃时，７０％ 胚胎出现畸形；４２℃时，１００％ 胚胎出现畸形。在同一温度条件下延长高温作用时间，对胚胎毒性作用增强。光镜观察可见神经上皮变薄，细胞排列紊乱，细胞数量减少等。结论：高热影响胚胎的生长发育，并与高温值和作用时间明显相关。
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| 关 键 词： | 高热 胚胎毒性 全胚胎培养 |
| 修稿时间： | 1998-09-10 |
Study on embryo toxicity of hyperthermia by use of whole embryo culture technique in vitro |
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| Zou Jiyan ,Zhao Yixuan ,Li Shourou ,Liu Ying. Study on embryo toxicity of hyperthermia by use of whole embryo culture technique in vitro[J]. Journal of Jilin University: Med Ed, 1999, 25(4): 431-432 |
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| Authors: | Zou Jiyan Zhao Yixuan Li Shourou Liu Ying |
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| Affiliation: | Zou Jiyan 1,Zhao Yixuan 1,Li Shourou 1,Liu Ying 2 |
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| Abstract: | Objective:To study the toxic effects of hyperthermia on development of rat embryo.Methods:Whole embryo culture technique in vitro was used.Results:The frequencies of malformation were 70% and 100% when the embryos were exposed to 40℃ and 42℃ 10 minutes,separately.The toxic effects increased if the duration of hyperthermia was prolonged for 15 minutes.Conclusion:Hyperthermia influenced the development of embryo,which significantly correlated with both the degree and duration of hyperthermia. |
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| Keywords: | hyperthermia embryo toxicity whole embryo culture |
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