| 磷酸化STAT3、bFGF在进行期寻常型银屑病皮损中的表达及意义 |
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| 引用本文： | 冯世军,杨秀芳,朱文胜,张广静,闫华. 磷酸化STAT3、bFGF在进行期寻常型银屑病皮损中的表达及意义[J]. 中国医药导刊, 2012, 0(9): 1579-1580 |
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| 作者姓名： | 冯世军 杨秀芳 朱文胜 张广静 闫华 |
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| 作者单位： | 1. 河北省沧州市中心医院皮肤科,沧州061000
2. 河北省青县人民医院皮肤科,青县062650 |
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| 基金项目： | 沧州市科技局项目“寻常型银屑病皮损中Stat3,Survivin,bFGF的表达及相关性研究”,编号:1123031ZD |
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| 摘 要： | 目的:探讨磷酸化信号传导及转录活化因子(P-STAT3)及碱性成纤维细胞生长因子(bFGF)在寻常型银屑病皮损中的表达及意义。方法:通过免疫组化方法研究36例寻常型银屑病皮损中P-STAT3及bFGF表达的情况,并探讨P-STAT3和bFGF表达的相关性。结果:寻常性银屑病皮损中,P-STAT3及bFGF阳性表达均明显高于正常对照组,差异均有统计学意义(P<0.05)。银屑病患者P-STAT3表达和bFGF表达呈正相关(P<0.01)。结论:P-STAT3和bFGF在进行期寻常型银屑病皮损中表达均升高,且呈正相关,提示两基因有可能共同参与银屑病的发生和发展。
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| 关 键 词： | Stat3 bFGF 银屑病 免疫组化 |
The Expression and Correlation of P-STAT3 and bFGF in Epidermal Skin Lesions of Patients with Active Psoriasis Vulgaris |
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| Affiliation: | Feng Shijun1,Yang Xiufang1,Zhu Wensheng2,et al.(1Department of Dermatology,Cangzhou Centre Hospital,Hebei Province,Cangzhou 061000,China;2Department of Dermatology of Qingxian People’s Hospital,Hebei Province,Qingxian 062650,China) |
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| Abstract: | Objective:To investigate the expression and association between of P-STAT3 and bFGF in the lesions of psoriasis vulgaris.Methods:Biopsy samples were obtained from 36 patients with psoriasis vulgaris,and subjected to immunohistochemical staining for P-STAT3 and bFGF.The results were analyzed and were analysed from the relevance of P-STAT3 and bFGF.Results:The expression of P-STAT3 and bFGF were significantly higher in the lesions than those in the controls with a statistically significant differences(P<0.05).Positive correlation was found between the expression of the two factors(P<0.01).Conclusion:The expression of P-STAT3 and bFGF were higher in lesion of psoriasis vulgaris,which indicated that two genes might contribute to the development of psoriasis. |
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| Keywords: | P-STAT3 bFGF Psoriasis Immunohistochemistry、 |
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