短效胰岛素强化治疗2型糖尿病32例疗效观察

目的:探讨短效胰岛素强化治疗2型糖尿病的临床疗效。方法:将64例确诊的2型糖尿病患者随机分为治疗组和对照组各32例。两组均给予常规糖尿病健康教育、保持运动量和饮食相对恒定;同时予以二甲双胍片口服、甘精胰岛素皮下注射。对照组加用瑞格列奈0.5mg～1.0mg,每日三餐前口服。治疗组在常规治疗基础上采用重组人胰岛素诺和灵R(100U/ml)作为泵用胰岛素行胰岛素泵治疗,初始量按每日0.5U/kg基础量与餐前量1:1输注。低血糖判定标准:血糖<3.5mmol/L。两组疗程均为2周。结果:治疗组总有效率92.59%,对照组总有效率75.00%,两组总有效率比较差异有统计学意义(P<0.05)。短效胰岛素强化治疗组和对照组治疗后FBG、2hPBG、HbA1C、FINS及IRI均明显降低,差异均具有统计学意义(P<0.01,P<0.05);治疗后,短效胰岛素强化治疗组FBG、2hPBG、HbA1C、FINS及IRI改善均显著优于对照组,差异具有统计学意义(P<0.01,P<0.05)。治疗组低血糖发生率为9.38%,对照组低血糖发生率为31.25%,两组比较差异具有统计学意义(P<0.05)。结论:短效胰岛素强化治疗2型糖尿病疗效肯定,且低血糖发生率低,值得临床推广使用。

Efficacy Observation of the Intensivetherapy of Short-acting Insulin for 32 Patients with Type 2 Diabetes

Objective:To discuss clinical curative effect of the intensivetherapy of short-acting insulin for type 2 diabetes.Methods:64 patients with diagnosed type 2 diabetes patients were randomly divided into treatment group and control group,and 32 cases constituted a group.All cases were given the conventional diabetes health education,kept the amount of exercise and diet relatively constant.At the same time,cases profess to convinced DMBG,and were subcutaneous injected insulin glargine.In control group,cases oral raigor column nye 0.5 mg ～ 1.0 mg everyday,before meals.In treatment group cases had the conventional treatment on the basis of recombinant human insulin’s spirit R(100 U/ml) as a pump use insulin line insulin pump therapy,and initial quantity according to the daily 0.5 U/kg basis before meal quantity and quantity 1:1 infusion.Hypoglycemia decision criteria:blood sugar < 3.5 mmol/L.Two groups treated 2 weeks.Results:Treatment group total effectiveness was 92.59%,and the comparison group total effectiveness was 75.00%.Compared total effective rates,p < 0.05.After treatment in short-acting insulin strengthening treatment group and the control group,FBC,2 HPBG,HbAI,FNS and IRI were significantly lower,differences are significant(P<0.01,P<0.05);After treatment,in short-acting insulin strengthening treatment group,FBC,2 HPBG,HbAI,FNS and IRI improve were significantly superior to control group,the difference is statistically significant(P<0.01,P<0.05).The treatment group was 9.38% incidence of hypoglycemia and control group was 31.25% in low incidence rate,the difference between the two groups have statistical significance(P<0.05).Conclusion:Strengthening short-acting insulin treatment for type 2 diabetes curative effect was be conformed,and hypoglycemia was happened lower,it is worth clinical promotion to be used.