| 鱼腥草素钠(粉针剂)体外抗菌活性的初步研究 |
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| 引用本文： | 程训民,沈继录,徐元宏,李敏,张琪,朱素珍.鱼腥草素钠(粉针剂)体外抗菌活性的初步研究[J].时珍国医国药,2005,16(5):F003-F004. |
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| 作者姓名： | 程训民 沈继录 徐元宏 李敏 张琪 朱素珍 |
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| 作者单位： | 1. 安徽省淮北市人民医院,235000
2. 安徽医科大学第一附属医院,安徽,合肥,230022 |
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| 摘 要： | 目的:测定鱼腥草钠(粉针剂)对临床常见致病菌的抗菌能力,以期评价其体外抗菌效果,为该药物粉针剂的开发和临床研究提供依据。方法:使用微量液体稀释法和琼脂稀释法测定鱼腥草素钠(粉针剂)不同条件下对临床常见致病菌最小抑菌浓度(MIC)和最小杀菌浓度(MBC)。结果:鱼腥草素钠(粉针剂)对革兰阴性杆菌(肺炎克雷伯菌、大肠埃希菌)和真菌(白色念珠菌)抗菌效果较差,MIC>10 2 4μg/ ml。对革兰阳性球菌(金黄色葡萄球菌、表皮葡萄球菌及肺炎链球菌)有较好抑制作用,其MIC在6 4μg/ ml左右,不同p H值和不同菌液浓度对鱼腥草素钠(粉针剂)的抗菌效果无明显影响。结论:鱼腥草素钠(粉针剂)对革兰阳性球菌(金黄色葡萄球菌、表皮葡萄球菌及肺炎链球菌)有较好抑制作用,值得进一步开发和利用。
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| 关 键 词： | 鱼腥草素钠 最小抑菌浓度 最小杀菌浓度 |
| 文章编号： | 1008-0805(2005)05-封 3-02 |
| 修稿时间： | 2004年11月1日 |
Initial Study on Sodium Houttuyfonate(injectable powder) Antimicrobial Activity in Vitro |
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| CHENG Xun-min,SHEN Ji-lu,XU Yuan-hong,LI Min,ZHANG Qi,ZHU Su-zhen.Initial Study on Sodium Houttuyfonate(injectable powder) Antimicrobial Activity in Vitro[J].Lishizhen Medicine and Materia Medica Research,2005,16(5):F003-F004. |
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| Authors: | CHENG Xun-min SHEN Ji-lu XU Yuan-hong LI Min ZHANG Qi ZHU Su-zhen |
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| Institution: | CHENG Xun-min1,SHEN Ji-lu2,XU Yuan-hong2,LI Min1,ZHANG Qi1,ZHU Su-zhen1 |
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| Abstract: | Objective:To evaluate Sodium Houttuy fo nate (injectable powder)antisepticize effect by determination antimicrobial acti vity in vitro which may be helpful to exploitation and clinical research.Methods:MIC and MBC were determined by microamount liquid dilution method and agar dilution method under different conditions.Results:It is not effective to gram negative bacilli and i s effective to gram positive coccus. Antimicrobial activity was not effective in different conditions.Conclusion:The gram positive coccus can be inhibited by So dium Houttuyfonate (injectable powder), which is value of further development an d utilization. |
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| Keywords: | Sodium Houttuyfonate MIC MBC |
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