| 紫杉醇联合卡培他滨治疗晚期胃癌的临床观察 |
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| 引用本文： | 张咏梅,张捷,潘春霞.紫杉醇联合卡培他滨治疗晚期胃癌的临床观察[J].中国肿瘤临床与康复,2010(2):134-136. |
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| 作者姓名： | 张咏梅 张捷 潘春霞 |
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| 作者单位： | 大连市肿瘤医院肿瘤科; |
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| 摘 要： | 目的观察紫杉醇联合卡培他滨治疗晚期胃癌的近期疗效及安全性。方法52例经病理确诊的晚期胃癌,接受紫杉醇联合卡培他滨联合化疗。紫杉醇175 mg/m2,d1;卡培他滨2 g/m2,d1～14,21 d一周期,至少化疗2周期后按WHO标准判断疗效及毒副反应。结果入组52例患者,均可评价疗效及不良反应。完全缓解0例,部分缓解22例,病情稳定30例,有效率42.3%,疾病控制率63.4%。初治组有效率57.1%,显著高于复治组25.0%（P=0.019）。主要不良反应有骨髓抑制,胃肠道反应,末梢神经毒性,多为Ⅰ～Ⅱ度,无化疗相关性死亡。结论紫杉醇联合卡培他滨治疗晚期胃癌,疗效较好,毒性低,是晚期胃癌患者的一种选择。
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| 关 键 词： | 紫杉醇 卡培他滨 胃肿瘤/化学疗法 |
Clincal observation of paclitaxel plus capecitabin for treatment of advanced gastric cancer |
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| ZHANG Yong-mei,ZHANG Jie,PAN Chun-xia.Clincal observation of paclitaxel plus capecitabin for treatment of advanced gastric cancer[J].Chinese Journal of Clinical Oncology and Rehabilitation,2010(2):134-136. |
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| Authors: | ZHANG Yong-mei ZHANG Jie PAN Chun-xia |
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| Institution: | ZHANG Yong-mei,ZHANG Jie,PAN Chun-xia(Department of Medical Oncology,Dalian Cancer Hospital,Dalian,116030,China) |
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| Abstract: | Objective To investigate the efficacy and toxicity of paclitaxel plus capecitabin as a chemotherapy regimen in treatment of patient with advanced gastric cancer(AGC).Methods Fifty-two patients were diagnosed to have AGC by pathological examination.All patients received paclitaxel 175mg/m2 as a 3-h infusion on day 1,capecitabin 2.0g/m2 on day 1 to 14.Treatment was repeated every 21 days.Results All the 52 patients were evaluated for response and toxicity.The overall response rate was 42.3%,with complete and ... |
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| Keywords: | Paclitaxel Capecitabin Stomach neoplasms/chemotherapy |
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