血清神经元特异性烯醇化酶淀粉样蛋白A及IL-6与动脉粥样硬化性卒中后神经损伤和预后关系

目的 探讨血清神经元特异性烯醇化酶(NSE)、血清淀粉样蛋白A(AA)、白介素-6(IL-6)与动脉粥样硬化性卒中后神经功能损伤及预后的关系.方法 选取2014年5月至2016年6月在安庆市立医院神经内科接受治疗的105例动脉粥样硬化性卒中患者作为研究对象,将NSE、AA、IL-6水平增高的患者作为试验组(n=66),水平正常者作为对照组(n=39),于入院当天采用美国国立卫生研究院卒中量表(NIHSS)评分,同时测量血清NSE、AA、IL-6水平,并在患者入院/起病第7、14天复查结果;在起病30天应用改良Rankin表(mRS)评价患者神经功能恢复情况.结果 ①试验组患者第1、7、14天NIHSS评分、血清NSE、AA、IL-6水平均高于对照组,差异有统计学意义(P＜0.05).②试验组患者第30天mRS评分为1～2分患者21例,3～4分患者26例,5～6分19例,与对照组比较差异有统计学意义(P＜0.05).结论 早期对动脉粥样硬化性卒中患者的血清NSE、AA、IL-6检测能够作为早期识别预后不良的动脉粥样硬化性卒中患者的指标.

Relationship of serum NSE, AA, IL-6 levels with nerve injury and prognosis after atherosclerotic stroke

Objective To investigate the relationship of serum levels of neuron-specific enolase (NSE),amyloid protein A (AA),interleukin-6 (IL-6) with neurological damage and prognosis in those patients with atherosclerotic stroke.Methods 105 cases of patients with atherosclerosis stroke,ever treated in our hospital from May 2014 to June 2016,were enrolled as the study objectives.The patients with increased levels of NSE,AA and IL-6 were divided into the study group (n =66),while those with normal levels were divided into the control group (n =39).At the day of hospital admission,all patients were evaluated with National Institutes of Health Stroke Scale (NIHSS) score,and their serum levels of NSE,AA and IL-6 were examined.At the 7th and 14th day after admission,they were detected again.The recovery of neurological function was assessed with modified Rankin Scale (mRS) score at 30 days after disease onset or hospital admission.Results At the 1 st,7th and 14th day,the NIHSS scores and serum levels of NSE,AA and IL-6 in the study group were significantly higher than those in the control group (all P ＜ 0.05).Compared with the control group,the mRS scores at the 30th day in the study group were 1 ～ 2 of 21 cases,3 ～ 4 of 26 cases,and 5 ～ 6 of 19 cases,respectively,with significant differences between the two groups (all P ＜0.05).Conclusion Early detection of serum NSE,AA and IL-6 levels in those patients with atherosclerotic stroke could be used as an indicator of identifying them with poor prognosis earlier.