Odanacatib抑制大鼠正畸复发的Micro-CT研究

研究局部注射odanacatib对大鼠正畸牙移动复发的影响.选取30只大鼠随机分为2组,每组15只,近中移动右上颌第一磨牙,加力3周去除加力装置让其复发.实验组于第一磨牙颊沟处注射odanacatib,对照组注射生理盐水.复发0d和2周时测量牙齿移动距离,计算复发率.复发2周后处死大鼠,对上颌骨牙槽骨扫描Micro-CT,测量骨矿物质密度(BMD)和骨体积分数(BVF)值.实验组复发率明显低于对照组(P＜0.05),且实验组牙槽骨的BMD和BVF值明显高于对照组(P＜0.05).局部注射odanacatib有效地抑制大鼠正畸牙齿移动后复发.

Odanacatib inhibits relapse of orthodontic tooth movement: an in vivo micro-CT analysis

To evaluated the inhibition effect of local injection of odanacatib on orthodontic relapse.Thirty rats were randomly divided into 2 groups(n =15).The maxillary right first molars of all animals were subjected to orthodontic force and moved mesially.Three weeks later,the force was removed,and the teeth relapsed.The rats of experimental group were received local injections of odanacatib.The control group received saline instead.Tooth movement and relapse were measured when appliances removed after 0 day and 2 weeks.The rats were sacrificed after the 2-week relapse.The microcomputed tomography analysis was performed to quantify the alveolar bone,and the values of bone mineral density(BMD) and bone volume fraction(BVF) were measured.The percentage of relapse in the experimental group was significantly lower than that in the control group(P ＜0.05),and the BMD and BVF of alveolar bone in the experimental group were significantly higher than those in the control group(P ＜0.05).Local injection of odanacatib effectively inhibit the relapse after orthodontic tooth movement in rats.