藏红花对酒精和酒精四氯化碳致大鼠肝损伤及脂质过氧化水平的影响

目的:探讨藏红花对酒精及酒精四氯化碳(CCl_4)致大鼠肝损伤和脂质过氧化的影响。方法:取雄性 Wistar 大鼠设5组,分别灌喂生理盐水(A 组)、白酒(B 组)、白酒加藏红花(C 组)、白酒和 CCl_4(D 组)、在 D 组基础上加用藏红花(E 组);5组大鼠血清丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)及肝脏组织学病变进行比较。结果:藏红花能降低白酒和 CCl_4引起的 MDA 升高(P<0.05);能提高大鼠血 GSH-Rx 水平;C、E 组与 B、D 组比较肝脏组织学观察炎症明显减轻。结论:藏红花能减轻酒精及酒精 CCl_4所致肝损伤和脂质过氧化。

Effect of Saffron on Ethanol or Ethanol plus CCl_4 Induced Liver Injury and Lipid Peroxidation in Rats

To explore the effect of saffron on spirit or CCl_4 induced liver injury and lipid peroxidation in rats.Methods:Five groups of male Wistar rats,10 in each group,were treated respectively with:normal saline(A),white spirit(B),white spirit saffron(C),white spirit CCl_4(D)and white spirit CCl_4 saffron(E)for 8 weeks.The level of serum rnalonyldialdehyde(MDA)and glutathione per- oxidase(GSH-Px)as well as pathologic change of liver were observed.Results:Saffron could lower the elevation of MDA and raise the lowering of GSH-Px induced by white spirit and CC14.As compared the tissue changes in Group C and E with those in Group B and D respectively,the inflammation was milder in the formers than that in the latters.Conclusion:Saffron could reduce the liver injury and lipid peroxidation induced by white spirit and CCl_4.