神经端侧吻合植入失神经皮瓣感觉功能研究

目的 探讨感觉神经端侧吻合后供神经的轴突长入神经移植体后，最终能否形成具有功能的感觉末梢。方法 用新西兰兔15只，将兔一条耳大神经做为供神经，在另侧耳取耳大神经移植体与供神经作端侧吻合后埋入失神经皮瓣，另设正常皮肤组和未植神经作对照组，每组动物5只。4个月后用神经单纤维放电技术观察皮瓣内再生神经纤维放电数量、 分布和类型。结果 对移植神经4个月的皮瓣进行神经电生理检查，见各类敏感纤维放电数量、分布和类型。结果 对移植神经4个月的皮瓣进行神经电生理检查，见各类敏感纤维放电均有出现，放电纤维总数在到正常皮肤经组的58％，而同期末植神经对照组，仅在皮瓣边缘靠近神经的一侧有极少放电。结论 神经端侧吻合方法可以重建皮瓣感觉功能。

A study on the functions of the regenerated axons in end-to-side neurorrhaphy

Objective To probe the possibility of functional sensory endings regeneration after end to side neurorrhaphy Methods Fifteen New Zealand rabbits were used in this study The left greater auricular nerve served as the donor nerve A nerve graft taken from the right ear served as the receptive nerve which anastomosed to the donor nerve with the other end implanting into the denervated skin flap Normal skin and denervated skin flap without nerve implantation served as control groups 5 animals in each group The single nerve fibre recording technique was used to investigate the number,distribution and types of regenerated discharging nerve fibers 4 months after operation Results The inductive discharges of nerve fibres wave observed in all types of regenerated sensory nerves,the total discharging fibers was about 58% of that in normal skin Few discharging fibers were observed in denervated skin flap without nerve implantation Conclusion End to ide neurorrhaphy can regenerate functional axons