Galectin-3 inhibits Schwann cell proliferation in cultured sciatic nerve |
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Authors: | Gustavsson Per Linsmeier Cecilia Eriksson Leffler Hakon Kanje Martin |
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Institution: | Department of Cell and Organism Biology, Lund University, Lund, Sweden. per.gustavsson@cob.lu.se |
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Abstract: | The production of galectin-3, a carbohydrate-binding mammalian lectin, is upregulated in Schwann cells after peripheral nerve injury in areas where Schwann cells proliferate. Here we tested if galectin-3 affected proliferation of Schwann cells in cultured sciatic nerve segments. Galectin-3 significantly decreased the number of bromodeoxyuridine-labelled Schwann cell nuclei. Neither lactose nor a synthetic inhibitor directed against the carbohydrate-binding region abolished the effects of galectin-3. In addition, a mutant galectin-3 unable to bind endogenous carbohydrates had similar effects as normal galectin-3. We conclude that galectin-3 reduces proliferation of Schwann cells in cultured sciatic nerve segments by a mechanism which is independent of its carbohydrate-binding moiety. |
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