不同麻醉方式对老年女性腹腔镜手术患者术后认知功能的影响

目的 探讨不同麻醉方式对老年妇科腹腔镜手术患者术后认知功能的影响.方法 选取老年患者60例,择期行妇科腹腔镜全子宫切除手术,根据随机对照原则,分为丙泊酚靶控输注麻醉组(P组)和七氟烷吸入麻醉组(S组),每组30例.比较2组患者呼吸恢复时间、苏醒时间及拔管时间;术前24 h及术后6 h、24 h、72 h及7 d采用简易...

Effects of different anesthesia methods on postoperative cognitive function of elderly patients undergoing gynecological laparoscopic surgery

Objective To explore the effects of different anesthesia methods on the postoperative cognitive function of elderly patients undergoing gynecological laparoscopic surgery.Methods A total of 60 elderly patients were selected for elective gynecological laparoscopic hysterectomy. According to the principle of randomized control, they were divided into two groups: target-controlled infusion of propofol anesthesia group(group P) and sevoflurane inhalation anesthesia group(group S). In terms of indicators, the respiratory recovery time, recovery time and extubation time of the two groups of patients were compared. The mini-mental state examination(MMSE) was used for cognitive function measurement at 24 h before operation and at 6 h, 24 h, 72 h and 7 d after operation. At 24 h before operation, 24 h and 72 h after operation, IL-6 and S100β protein were measured by enzyme-linked immunosorbent assay（ELISA）.Results After operation, the MMSE scores of the two groups were decreased initially and then increased. The MMSE scores of group P were higher than those of group S at 6 h, 24 h and 72 h after operation(P＜0.05). The incidence of postoperative cognitive dysfunction（POCD） at 24 h and 72 h after operation in group P was lower than that in group S(P＜0.05). The plasma IL-6 concentration of the two groups showed a rising trend. The IL-6 concentration of group P was significantly lower than that of group S at 24 h and 72 h after surgery(P＜0.05). The S100β protein level of the two groups was increased initially and then decreased. The S100β protein level of group P was significantly lower than that of group S at 24 h after operation(P＜0.05); at 72 h after operation, the S100β protein of the two groups was decreased to the preoperative level.The incidence of adverse reactions in group P was lower than that in group S(P＜0.05).Conclusion Compared with sevoflurane inhalation anesthesia in elderly patients undergoing gynecological laparoscopic total hysterectomy, propofol intravenous anesthesia has fewer effects on postoperative cognitive function, with quick recovery and fewer adverse reactions. Therefore, it is more preferable for anesthesia in elderly patients.