系统性红斑狼疮合并缺铁性贫血一例

SLE是一种典型的自身免疫性结缔组织疾病,可累及全身多个器官和组织。该文报告一例SLE合并缺铁性贫血患者,对其诊断、治疗和发生缺铁性贫血的机制进行分析。该例为28岁女性患者,入院诊断为SLE,经治疗病情稳定并纠正贫血后,再次出现中度贫血,给予口服和静脉铁剂治疗后患者贫血可短暂改善,考虑与其长期服用质子泵抑制剂有关,经停用质子泵抑制剂并继续予铁剂治疗,贫血缓解。该例诊治提示,SLE患者长期服用质子泵抑制剂可增加缺铁性贫血的发生风险,其机制可能是通过影响铁的吸收而发挥作用。

Systemic lupus erythematosus complicated with iron deficiency anemia: a case report

Systemic lupus erythematosus （SLE） is a typical autoimmune connective tissue disorder that can affect multiple organs and tissues throughout the body. In this article, one case of SLE complicated with iron deficiency anemia was reported, and the diagnosis, treatment and pathogenesis of SLE complicated with iron deficiency anemia were analyzed. The 28-year-old female patient was diagnosed with SLE upon admission. After corresponding treatment, the disease condition was stabilized and the symptom of anemia was mitigated. Subsequently, she developed moderate anemia again, which was temporarily alleviated after oral and intravenous iron therapy. It was considered to be associated with long-term use of proton pump inhibitors. The symptom of anemia was relieved by discontinuation of proton pump inhibitors and persistent iron therapy. The diagnosis and treatment of this case prompt that long-term use of proton pump inhibitors might increase the risk of iron deficiency anemia possibly by affecting the iron absorption in SLE patients.