四君子汤对妊娠期糖尿病患者血管内皮功能及妊娠结局的影响

目的:探讨四君子汤对妊娠期糖尿病(GDM)患者临床疗效、内皮功能、围产期及新生儿情况的影响。方法:124例GDM患者随机分为观察组和对照组,每组62例。对照组患者采用饮食、运动疗法及胰岛素治疗,观察组患者在对照组基础上给予口服四君子汤。观察比较两组患者治疗前后血糖代谢指标、临床治疗效果,治疗前后内皮功能相关指标,围产期情况、妊娠结局及新生儿结局。结果:观察组与对照组相比,治疗后空腹血糖(FBG)、餐后2 h血糖(2hPG)和糖化血红蛋白(HbA1C)水平分别为(5.20±0.78)mmol/L、(6.87±1.16)mmol/L和(6.14±1.23)%均较低。与观察组比较临床治疗总有效率为91.94%较高,血浆一氧化氮(NO)、一氧化氮合酶(NOS)水平分别为(92.26±15.47)μmol/L、(26.71±5.45)U/ml较高,非对称性二甲基精氨酸(ADMA)水平为(0.68±0.24)μmol/L较低,羊水过多及早产发生率较低,新生儿体重较高。结论:四君子汤治疗GDM患者不仅能有效改善患者血糖代谢,提高临床治疗疗效,降低患者围产期不良情况发生率,提高新生儿体重指数,还能有效改善患者血管内皮功能。

Effect of Sijunzi decoction on vascular endothelial function and pregnancy outcome in patients with gestational diabetes mellitu

Objective:To explore the effect of Sijunzi decoction on clinical efficacy,endothelial function,perinatal period and neonatal condition in patients with gestational diabetes mellitus(GDM).Methods:124 patients with GDM were randomly divided into observation group(n=62)and control group(n=62).The patients in the control group were treated with diet,exercise therapy and insulin,while the patients in the observation group were treated with oral Sijunzi decoction.The indexes of blood glucose metabolism,clinical treatment effect,related indexes of endothelial function,perinatal period,pregnancy outcome and neonatal outcome were observed and compared between the two groups before and after treatment.Results:After treatment,the fasting blood glucose(FBG),2-hour postprandial blood glucose(2hPG)and glycosylated hemoglobin(HbA1C)in the observation group were(5.20 ±0.78)mmol/L,(6.87 ±1.16)mmol/L and(6.14 ±1.23)%,respectively,which were lower than those in the control group,while the total effective rate of clinical treatment was 91.94%,which was higher than that in the control group.Plasma nitric oxide(NO)and nitric oxide synthase(NOS)were(92.26 ±15.47)μmol/L and(26.71 ±5.45)U/ml,respectively,which were higher than those in the control group.The level of asymmetric dimethylarginine(ADMA)was(0.68 ±0.24)μmol/L,lower than that of the control group.The incidence of polyhydramnios and premature delivery in the observation group was lower,and the neonatal weight was higher.Conclusion: Sijunzi decoction can effectively improve the blood glucose metabolism,improve the efficacy of clinical treatment,reduce the incidence of perinatal adverse conditions,improve the body mass of newborns,and effectively improve the vascular endothelial function of patients with GDM.