针刺临床研究中常用的Rs-fMRI分析方法:10年概况

Rs-fMRI是一种用于针刺临床中研究脑部活动的一种科学放法,Rs-fMRI分析方法可以辅助研究者得出研究结论,从而反馈于临床实践中。Rs-fMRI分析方法在近十年针刺临床研究中常用的有3种:局部一致性（ReHo）、低频振幅分析（ALFF）、功能连接性分析（FC）。ReHo在针刺研究中可用于研究某穴位激活或抑制,某个脑区或某几个脑区,从而得出该穴位的靶效应脑区,为研究“穴位-脑-疾病”打下基础;ALFF可直接反映局部神经元自发同步化神经活动的强度,在一定程度上反映各相关脑区间的相互作用和神经网络连接;FC可以得出脑区之间的功能连接,即脑区间的“高速路”,其简单易懂,结果直接。运用不同的分析方法可以显示针刺不同穴位的脑部活动,如局部神经活动的同步性、相邻脑区之间的连接性及大脑的自发波动及功能活动等。本文将阐述ReHo、ALFF、FC 3种分析方法在针刺研究中的适用研究方向。 

Brief Rs-fMRI analysis methods commonly used in clinical studies of acupuncture in recent 10 years

Rs- fMRI is a scientific method to explore brain activity in clinical acupuncture which assists researchers to draw research conclusions and provide feedback in clinical practice.There were three kinds of RS fMRI analysis methods commonly used in acupuncture clinical research in recent 10 years: Regional Homogeneity (ReHo), Amplitude Of Low Frequency Fluctuation (AlFF) and Functional Connectivity(FC). In acupuncture research, ReHo could be used to analyse the activation or inhibition of a acupoint in a certain or several brain regions, so as to acknowledge the target effect brain area of the acupoint, and lay a foundation for the study of acupoint-brain-disease. ALFF could directly reflect the intensity of spontaneous synchrony of local neurons, and to a certain extent, reflect the interaction and neural network connections of relevant brain regions. FC obtained the functional connections between brain regions, namely the highway of brain regions, which was easy to understand and the results are direct. Different analysis methods showed the brain activity of acupuncture at different acupoints, such as the synchronization of local nerve activity, the connectivity between adjacent brain areas, the spontaneous fluctuation and functional activity of the brain.This paper elaborates the applicable research directions of ReHo, ALFF and FC analysis methods in acupuncture research.