成人1型糖尿病患者抑郁发生现状与相关因素分析

目的 分析成人1型糖尿病（T1DM）患者抑郁现状及发病相关因素。方法 采用Zung氏抑郁自评量表评估291例T1DM患者的抑郁情况,收集其临床资料,用logistic回归分析抑郁发生的影响因素。结果 291例T1DM患者中抑郁发生率为48.1%。抑郁者合并糖尿病肾病百分率、焦虑自评量表（SAS）评分、尿白蛋白肌酐比值及血尿素氮水平均高于无抑郁者（P均 < 0.05）。logistic回归显示视网膜光凝治疗、 SAS评分及血尿素氮是T1DM患者抑郁的危险因素（OR分别为16.243、1.205及1.389,P均 < 0.05）。结论 抑郁在成人T1DM患者中发生率较高,与焦虑及糖尿病慢性并发症可能相关。

Occurrence status and risk factors of depression in adults with type 1 diabetes mellitus

Objective To analyze the incidence and risk factors of depression in adults with type 1 diabetes mellitus （T1DM）. Methods The depression of 291 T1DM patients was evaluated by Zung self-rating depression scale. Clinical data of all patients were collected. The risk factors of depression were identified by logistic regression analysis. Results The incidence of depression in 291 adults with T1DM was 48.11%. The percentage of patients complicated with diabetic nephropathy （DN）, self-rating anxiety scale （SAS） score, urinary albumin/creatinine and blood urea nitrogen （BUN） levels in T1DM adults with depression were significantly higher than those in their counterparts without depression （all P < 0.05）.Logistic regression analysis demonstrated that retinal photocoagulation, SAS score and BUN were the risk factors of depression in adults with T1DM （OR=16.243, 1.205 and 1.389, all P < 0.05）. Conclusion The incidence of depression in adults with T1DM is high, which is probably correlated with anxiety and chronic complications of T1DM.