支原体肺炎与细菌性肺炎炎性指标及血清降钙素原水平比较

目的 分析血清炎性细胞因子、血清降钙素原（PCT）、C反应蛋白（CRP）在支原体肺炎与细菌性肺炎中的水平变化及临床意义。方法 回顾分析2018年1月~2019年1月在我院诊治的90例儿童肺炎临床资料，其中诊断为支原体肺炎的51例设为观察A组，细菌性肺炎39例设为观察B组，另选取同期健康儿童40例设为对照组，比较各组血清炎性细胞因子（IL-6、IL-10）、PCT、CRP水平以及观察A组和观察B组急性期与缓解期血清PCT、CRP水平。结果 观察A组、观察B组IL-6水平均高于对照组，IL-10水平低于对照组，差异有统计学意义（P＜0.05），观察A组与观察B组IL-6、IL-10分别比较，差异无统计学意义（P＞0.05）；观察B组PCT水平高于对照组和观察A组，差异有统计学意义（P＜0.05），观察A组与对照组比较，差异无统计学意义（P＞0.05）；观察A组、观察B组CRP水平均高于对照组，且观察B组高于观察A组，差异有统计学意义（P＜0.05）；观察A组、观察B组急性期血清PCT、CRP 水平均高于缓解期，差异有统计学意义（P＜0.05）。结论 血清IL-6、IL-10、PCT和CRP有助于儿童支原体肺炎和细菌性肺炎的诊断，支原体肺炎和细菌性肺炎患儿炎性细胞因子水平基本相同，而PCT对细菌性肺炎诊断具有良好指导作用，可作为临床诊治中可靠的参考依据。

Comparison of Inflammatory Indexes and Serum Procalcitonin Levels in Mycoplasma Pneumonia and Bacterial Pneumonia

Objective To analyze the changes and clinical significance of serum inflammatory cytokines, serum procalcitonin （PCT）, and C-reactive protein （CRP） in mycoplasma pneumonia and bacterial pneumonia. Methods The clinical data of 90 children with pneumonia diagnosed and treated in our hospital from January 2018 to January 2019 were retrospectively analyzed. Among them, 51 cases diagnosed with Mycoplasma pneumonia were set as observation group A, and 39 cases of bacterial pneumonia were set as observation group B. In the same period, 40 healthy children were used as the control group, and serum inflammatory cytokines （IL-6, IL-10）, PCT, and CRP levels were compared in each group,the serum PCT and CRP in the acute and remission period between observation groups A and B were compared.Results The levels of IL-6 in observation group A and observation group B were higher than those in the control group, and the levels of IL-10 were lower than those in the control group,the difference was statistically significant（P<0.05）.There was no significant difference in IL-6 and IL-10 between observation group A and observation group B （P>0.05）;The PCT level in observation group B was higher than that in control group and observation group A,the difference was statistically significant（P<0.05）. There was no significant difference in observation group A compared with the control group （P>0.05）.The levels of CRP in observation group A and observation group B were higher than those in control group, and observation group B was higher than observation group A, the difference was statistically significant（P<0.05）; observation group A and observation group B’s serum PCT and CRP levels in acute phase all were higher than the remission period,the difference was statistically significant （P<0.05）.Conclusion Serum IL-6, IL-10, PCT and CRP are helpful for the diagnosis of mycoplasma pneumonia and bacterial pneumonia in children. The levels of inflammatory cytokines in children with mycoplasma pneumonia and bacterial pneumonia are basically the same, and PCT has a good diagnosis of bacterial pneumonia guiding role can be used as a reliable reference in clinical diagnosis and treatment.