2009 - 2019年呼和浩特市健康人群麻疹抗体水平分析

目的 分析呼和浩特市健康人群麻疹抗体水平，评价呼市免疫规划工作质量。方法 2009 - 2019年每年在全市随机抽取不同年龄组健康人群作为监测对象，采用酶联免疫吸附实验(ELISA)检测麻疹IgG抗体。结果 2009 - 2019年共检测健康人群血清样本3 564份，麻疹IgG抗体阳性率为93.8%，不同年份麻疹抗体阳性率差异有统计学意义（χ2 = 41.898，P＜0.001）。从年龄组看，麻疹抗体阳性率最低为8月龄～，阳性率为89.4%；其次是≥30岁，阳性率为89.8%；麻疹抗体阳性率最高为18 月龄～，阳性率达到100.0%，不同年龄人群间抗体阳性率差异有统计学意义（χ2 = 47.460，P＜0.001）。不同性别间抗体阳性差异无统计学意义（χ2 = 1.820,P = 0.186）。不同免疫史人群抗体阳性率差异有统计学意义（χ2 = 51.391 P＜0.001）。城区和农区人群麻疹抗体阳性率差异无统计学意义（χ2 = 0.051,P = 0.835）。结论 呼和浩特市健康人群麻疹抗体阳性率普遍较高，基本形成了预防麻疹的免疫屏障，但8月龄～和≥30岁年龄组抗体阳性率较低，建议提高8月龄婴儿麻疹成分疫苗接种的及时率, 同时根据疫情态势对集体生活和工作的大中专新生、新兵和外来务工人员开展麻疹成分疫苗的补充免疫和查漏补种。

Measles antibody levels in healthy population in Hohhot, 2009-2019

To analyze the measles antibody level of healthy population, and to evaluate the quality of the currentimmunization program. Methods From 2009 to 2019 in Hohhot, different age groups of healthy people were randomlyselected as the experimental subject, and Enzyme -Linked Immuno Sorbent Assay (ELISA) method was used to test theirmeasles IgG antibody positive rate. Results From 2009 to 2019, 3564 serum samples from healthy population were tested,93.8% samples of which were positive. The measles antibody positive rate had a significant difference in different years (χ2=41.898, P=0.000). The measles antibody positive rate had significant differences in different age groups (χ2= 47.460, P<0.001). The lowest measles antibody positive rate of 89.4% was from the age group “8 months”. The age group “≥30 yearsold” had the measles antibody positive rate of 89.8%. The highest measles antibody positive rate appeared in the age group“8 months of age”, which reached 100%. There was no significant difference in different genders (χ2=1.820, P=0.186). Themeasles antibody positive rate had significant differences in population with different immune histories (χ2=51.391, P<0.001).There was no significant difference between urban and rural areas (χ2=0.051, P=0.835). Conclusion The healthy populationmeasles antibody positive rate in Hohhot is generally on a higher level, and basically forms an immunologic barrier of measlesprevention. However, the age groups “8 months of age” &“≥30 years old” have low measles antibody positive rate. Accordingto the epidemic situation, improving the timeliness of measles vaccination, carrying out the measles vaccine supplementaryimmunization and inoculation for new college students, recruiting and siting staff who have the collective lives is suggestes