柴附青金汤治疗原发性痛经气滞血瘀证疗效研究

目的:探讨柴附青金汤治疗原发性痛经气滞血瘀证临床疗效及对血清血小板活化因子(PAF)和β-内啡肽(β-EP)水平的影响。方法:选取原发性痛经患者104例,按随机数字表法分为对照组和观察组,各52例。对照组患者在痛经疼痛发作时给予布洛芬缓释胶囊,0.3 g/次,2 次/d。观察组在对照组基础上,给予柴附青金汤内服治疗,1 剂/d,2 次/d,两组连续用药3个月经周期。比较两组月经周期时间和月经量; 痛经程度按视觉模拟评分(VAS)、痛经症状评分评价; 比较临床疗效以及血清PAF和β-EP水平。结果:治疗后,观察组月经周期时间、月经量均多于对照组,差异具有统计学意义(P<0.01)。与对照组比较,治疗后观察组VAS和痛经症状评分均低于对照组,差异具有统计学意义(P<0.01)。观察组总有效率为92.31%,高于对照组的75.00%,差异具有统计学意义(P<0.05)。与对照组比较,治疗后观察组血清PAF水平下降更明显,β-EP水平升高更明显,差异具有统计学意义(P<0.01)。结论:柴附青金汤治疗原发性痛经气滞血瘀证的疗效较好,且对血清PAF和β-EP水平具有调节作用。

Efficacy of Chaifu Qingjin decoction in the treatment of primary dysmenorrhea with syndrome of Qizhi Xueyu

Objective:To investigate the efficacy of Chaifu Qingjin decoction in the treatment of primary dysmenorrhea with syndrome of Qizhi Xueyu and the effect of serum levels of platelet activating factor(PFA)and β-endorphins(β-EP).Methods:104 primary dysmenorrheal patients were selected and divided into control group and observation group with 52 cases for each group, according to the random number table method.Patients in the control group were given with Ibuprofen sustained-release capsules(1 tablet/time,2 times/d).The observation group on the basis of the control group was treated with Chaifu Qingjin decoction(1 dose/d,2 times/d).Both groups were treated for 3 consecutive menstrual cycles.Menstrual cycle time and menstrual volume,visual analog score(VAS),dysmenorrhea severity,the clinical efficacy,and serum levels of PAF and β-EP were compared between the two groups.Results:After treatment,menstrual cycle time and menstrual volume in the observation group were evidently higher than the control group(P<0.01).Compared with the control group,scores of VAS and dysmenorrhea for the observation group were obviously lower than the control group after treatment(P<0.01).The total effective rate of the observation group 92.31% was significantly higher than the control group 75.00%(P<0.05).Compared with the control group,the serum level of PAF in the observation group decreased more significantly,and the serum level of β-EP was increased more significantly after treatment(P<0.01).Conclusion:The efficacy of Chaifu Qingjin decoction in the treatment of primary dysmenorrhea with syndrome of Qizhi Xueyu is better.The serum levels of PAF and β-EP are regulated.