实时剪切波弹性成像评价慢性肾脏病早期肾脏损害的价值

目的 探讨实时剪切波弹性成像（RT-SWE）技术在慢性肾脏疾病早期肾损害中的潜在应用价值。 方法 应用RT-SWE技术检测早期慢性肾病1~3期患者肾脏皮质杨氏模量均值（E_mean），与患者24 h尿蛋白定量、血肌酐值及肾穿刺活检病理间质纤维化程度作对比；引入年龄因素校正E_mean值（pyE_mean），比较早期慢性肾病各期患者pyE_mean值的差异。 结果 E_mean值在慢性肾病1~3期患者不同组的差异无统计学意义（P > 0.05）；根据患者年龄校正得出的pyE_mean值在慢性肾病1期与2期患者之间差异无统计学意义（P > 0.05），但1、2期与3期的差异有统计学意义（P < 0.05）。 结论 pyE_mean值排除了年龄对肾脏硬度值的影响，对评估早期慢性肾病患者肾脏纤维化程度可能具有重要的潜在应用价值，RT-SWE技术可以应用于慢性肾病早期肾损害评估。

Value of real-time shear wave elastography in evaluating the damage in chronic kidney disease

Objective To investigate the value of RT-SWE technology in early damage of chronic kidney disease. Methods E_mean modulus of renal cortex in patients with chronic kidney disease (stage 1-3) was detected by RT-SWE technique, which was compared with 24-hour urinary protein quantification, serum creatinine value and interstitial fibrosis degree in with renal biopsy. Age factor was introduced to adjust the E_mean value (pyE_mean). The differences of pyE_mean value in patients with early chronic kidney disease at all stages were compared. Results The difference in E_mean value between the groups of patients with chronic kidney disease stage 1-3 was not significant (P > 0.05).The difference in pyE_mean value obtained by age correction between stage 1 and stage 2 chronic kidney disease patients was not significant (P > 0.05). The difference between stage 1, 2 and 3 was significant (P < 0.05). Conclusions pyE_mean excludes the influence of age on renal hardness. It has important potential application value in the evaluation of renal fibrosis in early chronic kidney disease patients. RT-SWE technology can be used in the evaluation of early renal damage in chronic kidney disease.